Laboratoire de Biophotonique et Pharmacologie
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Mayeul COLLOT

Chargé de recherche (CR2) CNRS

Equipe Biophotonique des interactions moléculaires et cellulaires

Bureau/Salle : E 004-E 018

Telephone :(+33) +33 (0)3 68 85 42 66

Courriel : mayeul.collot unistra.fr

 

Dr. Mayeul Collot

Chargé de recherches CNRS (CNRS researcher)

E-mail : mayeul.collot unistra.fr

Room : E 004 – E 018

Tel : (+33) (0)3 68 85 42 66

 

Research

My research focuses on the development of molecular and nanostructured fluorescent probes based on different systems, which provide efficient fluorescent turn-on effects or spectral changes upon detection of cellular events (variation of pH, calcium concentration, reductive environment, ligand/receptor interaction, etc). I mainly developed calcium,1, 2, 3 pH4 and plasma membrane probes5 but I am also involved in project aiming at developing nano-sensors based on nanoparticles6 and new functionalizable polymeric fluorescent nanoparticles for bio-imaging and theranostic.7

 

Education/Career

I started studying biology and chemistry at the Université Pierre & Marie Curie (Paris VI) where I finally graduated in molecular chemistry. I started a PhD at the École Normale Supérieure (ENS) de Paris in 2004 on carbohydrate medicinal chemistry, more specifically in the synthesis of oligosaccharides. In 2008 I joined the Pr. Seeberger’s group as a postdoc (ETH Zürich and Max Planck Institute Berlin) where I worked on the automated synthesis of Glycocsaminoglycans and on multivalent carbohydrates systems. In 2010 I went back to Paris where I changed the topic of my research and where I started developing fluorescent probes and nanostructured sensors. In 2013, I obtained a CNRS researcher position in Strasbourg.

 

(1)  Collot, M. ; Ponsot, F. ; Klymchenko, A. S. Chem. Commun. 2017, in press.

(2)  Collot, M. ; Wilms, C. D. ; Bentkhayet, A. ; Marcaggi, P. ; Couchman, K. ; Charpak, S. ; Dieudonné, S. ; Häusser, M. ; Feltz, A. ; Mallet, J.-M. eLife 2015, 4, e05808.

(3)  Collot, M. ; Loukou, C. ; Yakovlev, A. V. ; Wilms, C. D. ; Li, D. ; Evrard, A. ; Zamaleeva, A. ; Bourdieu, L. ; Leger, J.-F. ; Ropert, N. ; Eilers, J. ; Oheim, M. ; Feltz, A. ; Mallet, J.-M. J. Am. Chem. Soc. 2012, 134 (36), 14923–14931.

(4)  Despras, G. ; Zamaleeva, A. I. ; Dardevet, L. ; Tisseyre, C. ; Magalhaes, J. G. ; Garner, C. ; Waard, M. D. ; Amigorena, S. ; Feltz, A. ; Mallet, J.-M. ; Collot, M. Chem. Sci. 2015, 6 (10), 5928–5937.

(5)  Collot, M. ; Kreder, R. ; Tatarets, A. L. ; Patsenker, L. D. ; Mely, Y. ; Klymchenko, A. S. Chem. Commun. 2015, 51 (96), 17136–17139.

(6)  Attia, M. F. ; Dieng, S. M. ; Collot, M. ; Klymchenko, A. S. ; Bouillot, C. ; Serra, C. A. ; Schmutz, M. ; Er-Rafik, M. ; Vandamme, T. F. ; Anton, N. Macromol. Biosci. 2017.

(7)  Zamaleeva, A. I. ; Collot, M. ; Bahembera, E. ; Tisseyre, C. ; Rostaing, P. ; Yakovlev, A. V. ; Oheim, M. ; de Waard, M. ; Mallet, J.-M. ; Feltz, A. Nano Lett. 2014, 14 (6), 2994–3001.