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Professeur (PRCE2) UNISTRA

Directeur d'unité

Equipe Biophotonique des interactions moléculaires et cellulaires

Bureau/Salle : E10-E026

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260.  D. KOSCHUT, L. RICHERT, GIUSEPPINA P., H.H. NIEMANN, Y. MELY, & V.ORIAN-ROUSSEAU. Live Cell Imaging Shows Hepatocyte Growth Factor-induced Met Dimerization. Biochim Biophys Acta. 2016, 1863, 1552-1558.

259.  D. DESPLANCQ, G. FREUND, S. CONIC, A-P. SIBLER, P. DIDIER, A. STOESSEL, M. OULAD-ABDELGHANI, M. VIGNERON, J. WAGNER, Y. MELY, B. CHATTON, L. TORA, & E. WEISS. Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells. Exp. Cell Res. 2016, 342, 45-58.

258.  K. VOLTZ, J. LEONARD, P. TOURON TOUCEDA, J. CONYARD, Z. CHAKER, J. GODET, A. DEJAEGERE, Y. MELY, S. HAACKE, & R.H. STOTE. Quantitative sampling of Manalo, 2007 #110conformational heterogeneity of a DNA hairpin using molecular dynamics simulations and ultrafast fluorescence spectroscopy. Nucleic Acids Res. 2016, 44, 3408-19. IF 9.11

257.  K. K. SHARMA, F. PRZYBILLA, T. RESTLE, J. GODET, and Y. MELY. FRET-based assay to Screen inhibitors of HIV-1 Reverse Transcriptase and nucleocapsid protein. Nucleic Acids Res. 2016, 44, e74. IF 9.11

256.  N.P.F. BARTHES, K. GAVVALA, D. DZIUBA, D. BONHOMME, I.A. KARPENKO, A.S. DABERT-GAY, D. DEBAYLE, A.P. DEMCHENKO, R. BENHIDA, M. BENOIT, Y. MELY*, & A. BURGER*. (*co-last authors) Dual emissive analogue of deoxyuridine as a sensitive hydration-reporting probe for discriminating mismatched from matched DNAs and DNA/DNA and DNA/RNA duplexes. J. Mat. Chem. C. 2016, 4, 3010-3017. IF 4.70

255.  Y. CHEN, O. MASKRI, F. CHAMINADE, B. RENE, J. BENKAROUN, J. GODET, Y. MELY, O. MAUFFRET, & P. FOSSE. Structural insights into the HIV-1 minus-strand strong-stop DNA. J. Biol. Chem. 2016, 291, 3468-82. IF 4.57.

254.  A. BELFETMI, L. ZARGARIAN, C. TISNE, D. SLEIMAN, N. MORELLET, E. LESCOP, O. MASKRI, B. RENE, Y. MELY, P. FOSSE, & O. MAUFFRET. Insights into the mechanisms of destabilization of RNA secondary structure by the HIV-1 nucleocapsid protein. RNA. 2016, 22, 506-17. IF 4.94.

253.  Y. NIKO, P. DIDIER, Y. MELY, G.I. KONISHI, & A. KLYMCHENKO. Bright and photostable push-pull pyrene dye visualizes lipid order variation between plasma and intracellular membranes. Sci. Rep. 2016, 6, 18870. IF 5.58.

252. C. SIMONSSON, G. BASTIAT, M. PITORREA, A.S. KLYMCHENKO, J. BEJAUDA, Y. MELY, & J.P. BENOIT. Inter-nanocarrier and nanocarrier-to-cell transfer assays demonstrate the risk of an immediate unloading of dye from labeled lipid nanocapsules. Eur. J. Pharm. Biopharm., 2016, 98, 47–56. IF = 4.62.

251.  M. COLLOT, R. KREDER, L.D. PATSENKER, Y. MELY & A. KLYMCHENKO. Bright Fluorogenic Squaraines with Tuned Cell Entry for Selective Imaging of Plasma Membrane vs Endoplasmic Reticulum. Chem. Comm. 2015, 51, 17136-9. IF = 6.78

250. M. ATTIA, N. ANTON, R. BOUCHAALA, P. DIDIER, Y. ARNTZ, N. MESSADDEQ, A. KLYMCHENKO, Y. MELY, & T.F. VANDAMME. Functionalization of nano-emulsions with amino-silica shell at the oil-water interface. RSC Adv., 2015, 5, 74353-74361. IF 3.71.

249  I.SHULOV, S. ONCUL, A. REISCH, Y. ARNTZ, M. COLLOT, Y. MELY, & A.S. KLYMCHENKO. Fluorinated counterion-enhanced emission of rhodamine aggregates : ultrabright nanoparticles for bioimaging and light-harvesting. Nanoscale, 2015, 7, 18198-210. IF 7.76.

248.  V.J. GREINER, L. KOVALENKO, N. HUMBERT, L. RICHERT, C. BIRCK, M. RUFF, O. A. ZAPOROZHETS, S. DHE-PAGANON, C. BRONNER, Y. MELY. Site-selective monitoring of the interaction of the SRA domain of UHRF1 with target DNA sequences labeled by 2-aminopurine. Biochemistry, 2015, 54, 6012-6020. IF 3.02.

247.  V. POSTUPALENKO, D. DESPLANCQ, I. ORLOV, Y. ARNTZ, D. SPEHNER, Y. MELY, B.P. KLAHOLZ, P. SCHULTZ, E. WEISS, & G. ZUBER. Protein Delivery System Containing a Nickel-immobilized Polymer for Multimerization of Affinity Purified His-tagged Proteins Enhances Cytosolic Transfer. Angew. Chem. Int. 2015, 54, 10583-10586. IF = 11.70.

246.  K. K. SHARMA, F. PRZYBILLA, T. RESTLE, C. BOUDIER, J. GODET, and Y. MELY. Reverse transcriptase in action : FRET-based assay for monitoring flipping and polymerase activity in real time. Anal. Chem. 2015, 87 : 7690-7697. IF = 5.97.

245.  Y. VOLZ, D. KOSCHUT, A. MATZKE, M.S. DIETZ, C. KARATHANASIS, L. RICHERT, M.G. WAGNER, Y. MELY, M. HEILEMANN, H. H. NIEMANN, & V. ORIAN-ROUSSEAU. Direct Binding of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor to CD44v6. Biosci. Rep. 2015, 35, pii : e00236. IF 2.85.

244.  P. NEUBERG, A. PERINO, E. MORIN-PICARDAT, N. ANTON, Z. DARWICH, D. WELTIN, Y. MELY, A.S. KLYMCHENKO, J.S. REMY, & A. WAGNER. Photopolymerized micelles of diacetylene amphiphile : physical characterization and cell delivery properties. Chem. Comm. 2015, 51, 11595-8. IF 6.72.

243.  K. TROFYMCHUK, L. PRODI, A. REISCH, Y. MELY, K. ALTENHONER, J. MATTAY, & A. KLYMCHENKO. Exploiting Fast Exciton Diffusion in Dye-Doped Polymer Nanoparticles to Engineer Efficient Photoswitching. J. Phys. Chem. Lett., 2015. J. Phys. Chem. Lett. 2015, 6, 2259-2264. IF 6.69

242.  A. REISCH, A. RUNSER, Y. ARNTZ, Y. MELY, & A. KLYMCHENKO. Charge-Controlled Nanoprecipitation as a Modular Approach to Ultrasmall Polymer Nanocarriers : Making Bright and Stable Nanoparticles. ACS Nano. 2015, 9, 5104-5116. IF 12.03

241.  N. KEMPF, P. DIDIER, V. POSTUPALENKO, B. BUCHER, & Y. MELY. Investigation by high resolution microscopy of the internalization of neuropeptide Y bound to its Y1 receptor. Methods Appl. Fluoresc. 2015, 3, 025004.  

240.  V. KILIN, O. GLUSHONKOV, L. HERDLY, A. KLYMCHENKO, L. RICHERT, & Y. MELY. Fluorescence lifetime imaging of membrane lipid order with a ratiometric fluorescent probe. Biophys. J. 2015, 108, 2521-2531. IF 3.83

239.  I.O. MELEZHYK, R.V. RODIK, N.V. IAVORSKA, A.S. KLYMCHENKO, Y. MELY, V.V. SHEPELEVYCH, L.M. SKIVKA, & V.I. KALCHENKO. Antibacterial Properties of Tetraalkylammonium and Imidazolium Tetraalkoxycalix[4]arene Derivatives. Anti-infective agents. 2015, 13, 87-94.

238.  N. P. F. BARTHES, I.A. KARPENKO, D. DZIUBA, M. SPADAFORA, J. AUFFRET, A.P. DEMCHENKO, Y. MELY, E. BENHIDA, B.Y. MICHEL, & A. BURGER. Development of environmentally sensitive fluorescent and dual emissive deoxyuridine analogues. RSC Advances. 2015, RSC Adv, 2015, 5, 33536-33545. IF 3.71

237.  M. MORI, L. KOVALENKO, S. LYONNAIS, D. ANTAKI, B.E. TORBETT, M. BOTTA, G. MIRAMBEAU, & Y. MELY. Nucleocapsid Protein : a Desirable Target For Future Therapies Against HIV-1. Curr. Top. Microbiol. Immunol. 2015, 389, 53-92. IF 3.47

236. R. KREDER, K.A. PYRSHEV, Z. DARWICH, O.A. KUCHERAK, Y. MELY, & A.S. KLYMCHENKO. Solvatochromic Nile Red Probes with FRET Quencher Reveal Lipid Order Heterogeneity in Living and Apoptotic Cells. ACS Chem. Biol., 2015, 10, 1435-42 IF 5.44.

235.  M. SHOLOKH, R. SHARMA, D. SHIN, R. DAS, O.A. ZAPOROZHETS, Y. TOR, & Y. MELY. Conquering 2-aminopurines deficiencies : highly emissive isomorphic guanosine surrogate faithfully monitors guanosine conformation and dynamics in DNA.  J. Am. Chem. Soc., 2015, 137, 3185-8. IF 11.44.

234.  R. KREDER, S. ONCUL, O.A. KUCHERAK, K.A. PYRSHEV, E. REAL, Y. MELY, & A. KLYMCHENKO. Blue fluorogenic probes for cell plasma membranes fill the gap in multicolour imaging. RSC Adv., 2015, 5, 22899–22905. IF 3.71

233.  S.E. EL MESHRI, D. DUJARDIN, L. RICHERT, C. BOUDIER, J. GODET, J.L. DARLIX, P. DIDIER, Y. MELY*, & H. de ROCQUIGNY*. * corresponding authors. Role of the nucleocapsid domain in HIV-1 Gag oligomerization and trafficking to the plasma membrane : a fluorescence lifetime imaging microscopy investigation. J. Mol. Biol., 2015, 427, 1480-94. IF 3.96

232.  A. BOUKHARI, M. ALHOSIN, C. BRONNER, K. SAGINI, C. TRUCHOT, E. SICK, V.B. SCHINI-KERTH, P. ANDRE, Y. MELY, M. MOUSLI, & J.P. GIES. CD47 Activation-induced UHRF1 Over-expression Is Associated with Silencing of Tumor Suppressor Gene p16INK4A in Glioblastoma Cells. Anticancer Res., 2015, 35, 149-157. IF 1.87.

231.  I.A. KARPENKO, A.S. KLYMCHENKO, S. GIORIA, R. KREDER, I. SHULOV, P. VILLA, Y. MELY, M. HIBERT & D. BONNET. Squaraine as bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging. Chem. Comm., 2015, 51, 2960-2963. IF 6.72.

230.  I. KARPENKO, M. COLLOT, L. RICHERT, C. VALENCIA, P. VILLA, Y. MELY, M. HIBERT, D. BONNET, A.S. KLYMCHENKO. Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging. J. Am. Chem. Soc., 137, 405-412. 2015. IF 11.44.

229. H. ANTON, N. TAHA, E. BOUTANT, L. RICHERT, H. KHATTER, B. KLAHOLZ, P. RONDE, E. REAL, H. de ROCQUIGNY, & Y. MELY. Investigating the cellular distribution and interactions of HIV-1 Nucleocapsid protein by quantitative fluorescence microscopy. Plos one, 2015, 10, e0116921. IF 3.53

228. A.P. DEMCHENKO, G. DUPORTAIL, S. ONCUL, A.S. KLYMCHENKO & Y. MÉLY. Introduction to fluorescence probing of biological membranes. Methods in molecular biology, 2015, 1232, 19-43. IF 1.29.

227.  N. KEMPF, V. POSTUPALENKO, S. BORA, P. DIDIER, Y. ARNTZ, H. de ROCQUIGNY, & Y. MELY. The HIV-1 nucleocapsid protein recruits negatively charged lipids to ensure its optimal binding to lipid membranes. J Virol., 2015, 89, 1756-67. IF 4.85.

226.  A. GHOSE, M. REBARZ, O.V. MALTSEV, L. HINTERMANN, C. RUCKEBUSCH, E. FRON, J. HOFKENS, Y. MELY, P. NAUMOV, M. SLIWA, & P. DIDIER. Emission Properties of Oxyluciferin and its Derivatives in Water : Revealing the Nature of the Emissive Species in Firefly Bioluminescence. J. Phys. Chem. B, 2015, 119, 2638-2649. IF 3.61

225.  R.V. RODIK, A.S. ANTHONY, V.I. KALCHENKO, Y. MELY, & A.S. KLYMCHENKO. Cationic amphiphilic calixarenes to compact DNA into small nanoparticles for gene delivery. New. J. Chem., 2015, 39, 1654-64. IF 3.16.

224. M. SHOLOKH, O.M. ZAMOTAIEV, R. DAS, V.Y. POSTUPALENKO, L. RICHERT, D. DUJARDIN, O.A. ZAPOROZHETS, V.G. PIVOVARENKO, A.S. KLYMCHENKO, & Y. MELY. Fluorescent amino acid undergoing excited state intramolecular proton transfer for site-specific probing and imaging of peptide interactions. J. Phys. Chem. B, 2015, 119, 2585-2595. IF 3.61

223.  M.F. ATTIA, N. ANTON, M. CHIPER, R. AKASOV, H. ANTON, N. MESSADDEQ, S. FOURNEL, A. KLYMCHENKO, Y. MELY, & T.F. VANDAMME. Biodistribution of X-ray iodinated contrast agent in nano-emulsions is controlled by the chemical nature of the oily core. ACS Nano, 2014, 8, 10537-10550. IF 12.03.

222.  Y. NIKO, Y. ARNTZ, Y. MELY, G.-I. KONISHIA, & A. KLYMCHENKO. Disassembly-driven fluorescence turn-on of polymerized micelles by reductive stimuli in living cells. Chemistry, 2014, 20, 16473-16477. IF 5.93.

221.  J. VALANCIUNAITE, A.S. KLYMCHENKO, A. SKRIPKA, L. RICHERT, S. STEPONKIENE, G. STRECKYTE, Y. MELY, & R. ROTOMSKIS. A non-covalent complex of quantum dots and chlorin e6 : efficient energy transfer and remarkable stability in living cells revealed by FLIM. RSC Advances, 2014, 4, 52270-52278. IF · 3.71.

220.  K. TROFYMCHUK, A. REISCH, I. SHULOV, Y. MELY, & A. KLYMCHENKO. Tuning color and photostability of perylene diimides inside polymer nanoparticles : towards biodegradable substitutes of quantum dots. Nanoscale, 2014, 6, 12934-12942. IF 6.73.

219.  O.M. ZAMOTAIEV, V.Y. POSTUPALENKO, V.V. SHVADCHAK, V.G. PIVOVARENKO, A.S. KLYMCHENKO, & Y. MELY. Monitoring penetratin interactions with lipid membranes and cell internalization using a new hydration-sensitive fluorescent probe. Org. Biomol. Chem. 2014, 12, 7036-7044. IF 3.57.

218. J. BOISRAME-HELMS, X. DELABRANCHE, A. KLYMCHENKO, J. DRAI, E. BLOND, F. ZOBAIRI, Y. MELY, M. HASSELMANN, F. TOTI, & F. MEZIANI. Lipid emulsions differentially affect LPS-induced acute monocytes inflammation : In Vitro Effects on Membrane Remodeling and Cell Viability. Lipids, 2014, 49, 1091-1099. IF 2.56.

217.  M. MORI, A. NUCCI, M.C. DASSO LANG, N. HUMBERT, C. BOUDIER, F. DEBAENE, S. SANGLIER-CIANFERANI, M. CATALA, P. SCHULT-DIETRICH, U. DIETRICH, C. TISNE, Y. MELY, & M. BOTTA. Functional and Structural Characterization of a 2-amino-4-phenylthiazole inhibitors of the HIV-1 Nucleocapsid Protein with Antiviral Activity. ACS Chem Biol, 2014, 9, 1950-1955. IF 5.44.

216.  H. de ROCQUIGNY, S.E. EL MESHRI, L. RICHERT, P. DIDIER, J.L. DARLIX, & Y. MELY. Role of the Nucleocapsid region in HIV-1 Gag assembly as investigated by quantitative fluorescence-based microscopy. Vir. Res., 2014, 193, 78-88. IF 2.81.

215.  L. ZARGARIAN, C. TISNE, P. BARRAUD, N. MORELLET, B. RENE, Y. MELY, P. FOSSE, & O. MAUFFRET. Dynamics of linker residues modulate the nucleic acid binding properties of the HIV-1 nucleocapsid protein zinc fingers. PLOS one, 2014, 9, e102150. IF 3.53.

214. J.L. DARLIX, H. de ROCQUIGNY, O. MAUFFRET, & Y. MELY. Retrospective on the all-in-one retroviral nucleocapsid protein. Vir. Res., 2014, 193, 2-15. IF = 2.81

213.  A. REISCH, P. DIDIER, L. RICHERT, S. ONCUL, Y. ARNTZ, Y. MELY, & A. KLYMCHENKO. Collective fluorescence switching of counterion-assembled dyes in polymer nanoparticles. Nat. Comm. 2014, 5, 4089. IF 10.74.

212.  R.V. RODIK, A.S. KLYMCHENKO, Y. MELY, & V.I. KALCHENKO. Calixarenes and related macrocycles as gene delivery vehicles. J. Inclusion Phenomena and Macrocyclic Chemistry. 2014, 80, 189-200. IF = 1.40.

211. N. JAIN, Y. ARNTZ, S. ERCELEN, Y. MELY, & A.S. KLYMCHENKO. Synthesis and self-assembly of new unsymmetrical bolaamphiphiles : spontaneous monolayer formation on mica surface. J. Nanosci. Lett. 2014, 4, 38.

210.  A. NIEHL, A. PASQUIER, I. FERRIOL, A. ARNOLD, Y. MELY, & M. HEINLEIN. Comparison of the Oilseed rape mosaic virus and Tobacco mosaic virus movement proteins (MP) reveals common and dissimilar MP functions for tobamovirus spread. Virology. 2014, 456, 43-54.IF = 3.37.

209.  V. KILIN, H. ANTON, N. ANTON, E. STEED, J. VERMOT, T.F. VANDAMME, Y. MELY, & A.S. KLYMCHENKO. Counterion-enhanced cyanine dye loading into lipid nano-droplets for single particle tracking in zebrafish. Biomaterials, 35, 4950-7. IF = 8.50.

208.  S. MAILLOT, A. CARVALHO, J-P. VOLA, C. BOUDIER, Y. MELY, S. HAACKE, & J. LEONARD. Out-of-Equilibrium Biomolecular Interactions Monitored with Picosecond Fluorescence in Microfluidic Droplets. Lab Chip., 2014, 14, 1767-1774. IF = 5.70.

207.  Z. DARWICH, A.S. KLYMCHENKO, D. DUJARDIN, & Y. MELY. Imaging lipid order changes in endosome membranes of live cells by using a Nile Red-based membrane probe. RSC Adv., 2014, 4, 8481 – 8488. IF 3.71.

206.  C. DOEBELIN, P. WAGNER, F. BIHEL, N. HUMBERT, C.A. KENFACK, Y. MELY, J.J. BOURGUIGNON, & M. SCHMITT. Fully Regiocontrolled Polyarylation of Pyridine. J. Org. Chem. 2014, 79, 908-18. IF = 4.56

205. V.J. GREINER, F. RONZON, E. LARQUET, N. IKHELEF, F. GRECO, S. NAVILLE, P.E. MILHIET, C. MANIN, A. KLYMCHENKO, & Y. MELY. Characterization of the structural modifications accompanying the loss of HBsAg particle immunogenicity. Vaccine, 2014, 32, 1049-1054. IF = 3.5.

204.  A. JAKHMOLA, N. ANTON, H. ANTON, N. MESSADDEQ, F. HALLOUARD, A. KLYMCHENKO, Y. MELY & T.F. VANDAMME. Poly-ε-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography. Biomaterials, 2014, 35, 2981-2986. IF = 8.5.

203. I.A. KARPENKO, R. KREDER, C. VALENCIA, P. VILLA, C. MENDRE, B. MOUILLAC, Y. MELY, M. HIBERT, D. BONNET, & A.S. KLYMCHENKO. Red Fluorescent Turn-On Ligands for Imaging and Quantifying G Protein-Coupled Receptors in Live Cells. ChemBioChem. 2014, 15, 359-363. IF = 3.74.

202.  C. BOUDIER, N. HUMBERT, F. CHAMINADE, Y. CHEN, H. de ROCQUIGNY, J. GODET, O. MAUFFRET, P. FOSSE, & Y. MELY. Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription. Nucleic Acids Res. 2014, 42, 1065-1078. IF = 8.80.

201.  D. DZIUBA, I.A. KARPENKO, N. P. F. BARTHES, B.Y. MICHEL, A.S. KLYMCHENKO, R. BENHIDA, A.P. DEMCHENKO, Y. MELY, & A. BURGER. Rational design of a solvatochromic fluorescent uracil analogue with dual-band ratiometric response based on 3-hydroxychromone. Chem.
- Eur. J., 2014, 20, 1998-2009. IF = 5.8.

200. A. FERRAND, S. EAP, L. RICHERT, S. LEMOINE, D. KALASKAR, S. DEMOUSTIER-CHAMPAGNE, H. ATMANIF, Y. MELY, D. MAINARD, G. SCHLATTER, L. KUHN, G. LADAM, N. BENKIRANE-JESSEL. Osteogenetic Properties of Electrospun Nanofibrous PCL Scaffolds Equipped with Chitosan-based Nanoreservoirs of Growth Factors. Macromol. Biosci. 2014, 14, 45–55. IF = 3.74.

199. R. DAS, G. DUPORTAIL, A. GHOSE, L. RICHERT, A. KLYMCHENKO, S. CHAKRABORTYC, S. YESYLEVSKYY, & Y. MELY. Tuning Excited-State Proton Transfer Dynamics of a 3-hydroxychromone Dye in Supramolecular Complexes via Host-Guest Steric Compatibility. Phys. Chem. Chem. Phys. 2014, 16, 776-784. IF = 3.8

198.  V.Y. POSTUPALENKO, O.M. ZAMOTAIEV, V.V SHVADCHAK, A.V. STRIZHAK, V.G. PIVOVARENKO, A.S. KLYMCHENKO, & Y. MELY. Dual-Fluorescence L-Amino Acid Reports Insertion and Orientation of Melittin Peptide in Cell Membranes. Bioconj. Chem. 2013, 24, 1998-2007. IF = 4.58

197.  M. BALTZINGER, K.K. SHARMA, Y. MELY, & D. ALTSCHUH. Dissecting the oligonucleotide binding properties of a disordered chaperone protein using surface plasmon resonance. Nucleic Acids Res., 2013, 41, 10414-10425. IF = 8.80.

196.  M.F. PRODANOV, N.V. POGORELOVA, A.P. KRYSHTAL, A.S. KLYMCHENKO, Y. MELY, V.P. SEMYNOZHENKO, A.I. KRIVOSHEY, Y.A. REZNIKOV, S. YARMOLENKO, J.W. GOODBY,  & V.V. VASHCHENKO. Thermodynamically Stable Dispersions of Quantum Dots in a Nematic Liquid Crystal. Langmuir, 2013, 29, 9301-9. IF = 4.2

195. M. KRIFA, M. ALHOSIN, C.D. MULLER, J.P. GIES, L. CHEKIR-GHEDIRA, K. GHEDIRA, Y. MELY, C. BRONNER, & M. MOUSLI. Limoniastrum guyonianum aqueous gall extract induces apoptosis inhuman cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation. J. Exp. Clin. Cancer Res., 2013, 32, 30. IF = 2.15.

194.  J. BATISSE, S.X. GUERRERO, S. BERNACCHI, L. RICHERT, J. GODET, V. GOLDSCHMIDT, Y. MELY, R. MARQUET, H. de ROCQUIGNY, & J.C. PAILLART. APOBEC3G impairs the multimerization of the HIV-1 Vif protein in living cells. J. Virol. , 2013, 87, 6492-506. IF = 5.40.

193.  Z. DARWICH, O.A. KUCHERAK, R. KREDER, L. RICHERT, R. VAUCHELLES, Y. MELY*, A.S. KLYMCHENKO* co-last authors. Rational design of fluorescent membrane probes for apoptosis based on 3-hydroxyflavone. Methods Appl. Fluoresc., 2013, 1, 025002 (13 pages).

192.  B. MAILLOT, S. EILER, C. CRUCIFIX, F. GRANGER, L. RICHERT, P. DIDIER, J. GODET, N. LEVY, K. PRADEAU, S. EMILIANI, A NAZABAL, Y. MELY, D. MORAS, P. SCHULTZ, & M. RUFF. Structural and functional role of INI1 in the early step of HIV-1 infection. Plos One, 2013, 8, e60734 (14 pages). IF = 4.09.

191.  J. GODET, C. KENFACK, F. PRZYBILLA, L. RICHERT, G. DUPORTAIL, & Y. MELY. Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer. Nucleic Acids Res., 2013, 41, 5036-48. IF = 8.03.

190.  A.S. RINALDI, G. FREUND, D. DESPLANCQ, A.P. SIBLER, M. BALTZINGER, N. ROCHEL, Y. MELY, P. DIDIER, & E. WEISS. The use of fluorescent intrabodies to detect endogenous gankyrin in living cancer cells. Exp Cell Res. 2013. 319, 838-849. IF = 3.60.

189.  J.E. BASSARD, L. RICHERT, J. GEERINCK, H. RENAULT, F. DUVAL, P. ULLMANN, M. SCHMITT, E. MEYER, J. MUTTERER, W. BOERJAN, G. DE JAEGER, Y. MELY, A. GOOSSENS, D. WERCK-REICHHART. Protein-Protein and Protein-Membrane Associations in the Lignin Pathway. Plant Cell, 2012, 24, 4465-82. IF = 10.24.

188.  A.V. STRIZHAK, V.Y. POSTUPALENKO, V.V. SHVADCHAK, N. MORELLET, E. GUITTET, V. G. PIVOVARENKO, A.S. KLYMCHENKO, & Y. MELY. Two-Color Fluorescent L-Amino Acid Mimic of Tryptophan for Probing Peptide-Nucleic Acid Complexes. Bioconjug. Chem. 2012, 23, 2434−2443. IF=4.93.

187. T. VERCRUYSSE, B. BASTA, W. DEHAEN, N. HUMBERT, J. BALZARINI, F. DEBAENE, S. SANGLIER-CIANFERANI, C. PANNECOUQUE, Y. MELY*, & D. DAELEMANS*. * co-last authors. A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions. Retrovirology. 2012, 9, 95. IF = 6.5¶

186.  A.S. KLYMCHENKO, E. ROGER, N. ANTON, H. ANTON, I. SHULOV, J. VERMOT, Y. MELY*, T. VANDAMME*. * co-last authors. Highly lipophilic fluorescent dyes in nano-emulsions : towards bright non-leaking nano-droplets. RSC Adv., 2012, 2, 11876-11886.

185.  A. NIEHL, K. AMARI, D. GEREIGE, K. BRANDNER, Y. MELY, & M. HEINLEIN. Control of Tobacco Mosaic Virus Movement Protein Fate by cell-division-cycle Protein 48 (CDC48). Plant Physiol., 2012, 24, 4465-4482. IF = 7.1.

184. Z. DARWICH, A.S. KLYMCHENKO, O.A. KUCHERAK, L. RICHERT, & Y. MELY. Detection of apoptosis through the lipid order of the outer plasma membrane leaflet. Biochim. Biophys. Acta Biomembranes, 2012, 1818, 3048-3054. IF = 4.11.

183. J. GODET, C. BOUDIER, N. HUMBERT, R. IVANYI-NAGY, J.L. DARLIX, & Y. MELY. Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1. Virus Res., 2012, 169, 349-360. IF=2.9.

182.  V.J. GREINER, F. RONZON, E. LARQUET, B. DESBAT, C. ESTEVES, J. BONVIN, F. GRECO, C. MANIN, A. KLYMCHENKO, & Y. MELY. The structure of HBsAg particles is not modified upon their adsorption on aluminium hydroxide gel. Vaccine, 2012, 30, 5240-5245. IF=3.6.

181. M. MORI, P. SCHULT-DIETRICH, B. SZAFAROWICZ, N. HUMBERT, F. DEBAENE, S. SANGLIER-CIANFERANI, U. DIETRICH, Y. MELY, & M. BOTTA. Use of Virtual Screening for Discovering Anti-retroviral Compounds Interacting with the HIV-1 Nucleocapsid Protein. Virus Res., 2012, 169, 377-387. IF=2.9.

180  D. DZIUBA, V. POSTUPALENKO, M. SPADAFORA, A. KLYMCHENKO, V. GUERINEAU, Y. MELY, R. BENHIDA, & A. BURGER. A universal nucleoside with strong two-band fluorescence and environment sensitivity for investigating DNA interactions. J. Am. Chem. Soc., 2012, 134, 10209-10213. IF=9.0.

179.  A. BAZZI, L. ZARGARIAN, F. CHAMINADE, H. de ROCQUIGNY, B. RENE, Y. MELY, P. FOSSE, & O. MAUFFRET. Intrinsic nucleic acid dynamics modulates HIV-1 nucleocapsid protein binding to its targets. Plos One, 2012, 7, e38905. IF=4.4.

178.  C.A KENFACK, A.S. KLYMCHENKO, G. DUPORTAIL, A. BURGER, & Y. MELY. Ab initio study of solvent H-bonding effect on ESIPT reaction and electronic transitions of 3-hydroxychromone derivatives. Phys. Chem. Chem. Phys. 2012, 14, 8910-8918. IF=3.9.

177. R. DAS, G. DUPORTAIL, L. RICHERT, A. KLYMCHENKO, & Y. MELY. Sensing Micelle Hydration by Proton Transfer Dynamics of a 3-hydroxychromone Dye : The Role of Surfactant Headgroup and Chain Length. Langmuir, 2012, 28, 7147-7159. IF 4.3.

176.  N. ANTON, F. BALLY, C. SERRA, A. ALI, Y. ARNTZ, Y. MELY, M. ZHAO, E. MARCHIONI, A. JAJHMOLA, & T.F. VANDAMME. A new microfluidic setup for precise control of polymer nanoprecipitation process and lipophilic drug encapsulation. Soft Matter, 2012, 8, 10628-10636. IF = 5.0.

175.  V.G. PIVOVARENKO, O.M. ZAMOTAIEV, V.V. SHVADCHAK, V.Y. POSTUPALENKO, A.S. KLYMCHENKO, & Y. MELY. Quantification of local water concentration in biomolecules using dual-fluorescence labels. J. Phys. Chem. A., 2012, 116, 3103-3109. IF=2.7.

174.  G. LERICHE, G. BUDIN, Z. DARWICH, D. WELTIN, Y. MELY, A. KLYMCHENKO, & A. WAGNER. A FRET-based probe with a chemically deactivatable quencher. Chem Comm. 2012, 48, 3224-3226. IF=5.6

173.  N. JAIN, V. GOLDSCHMIDT, S. ONCUL, Y. ARNTZ, G. DUPORTAIL, Y. MELY, & A.S. KLYMCHENKO. Lactose-ornithine bolaamphiphiles for efficient gene delivery in vitro. Int. J. Pharm., 2012, 423, 392-400. IF=3.8

172. O. A. KUCHERAK, L. RICHERT, Y. MELY, & A.S. KLYMCHENKO. Dipolar 3-methoxychromones as highly fluorescent and photostable solvatochromic dyes. Phys. Chem. Chem. Phys. 2012, 14, 2292-2300. IF=3.9

171.  A. JOUANONG, P. DIDIER, & Y. MELY. Identification of a thermally activated process in the Cy3 photobleaching mechanism. Phys. Chem. Chem. Phys. 2012, 14,1585-1588. IF=3.9

170.  K.K. SHARMA, H. DE ROCQUIGNY, J.L. DARLIX, J.P. LAVERGNE, F. PENIN, J.M. LESSINGER, & Y. MELY. Analysis of the RNA chaperoning activity of the Hepatitis C virus Core protein on the conserved 3’X region of the viral genome. Nucleic Acids Res., 2012, 40, 2540-2553. IF=7.8.

169.  S.V AVILOV, C. BOUDIER, M. GOTTIKH, J.L. DARLIX, & Y. MELY. Characterization of the inhibition mechanism of the HIV-1 nucleocapsid protein chaperone activities by methylated oligoribonucleotides. Antimicrob. Agents and Chemother. 2012, 56, 1010-1018.IF=4.7

168  C. GUICHARD, R. IVANYI-NAGY, K. SHARMA, C. GABUS, D. MARC, Y MELY., & J.L. DARLIX. Analysis of nucleic acid chaperoning by the prion protein and its inhibition by oligonucleotides. Nucleic Acids Res., 2011, 39, 8544-8558. IF=7.8.

167. I. KANEVSKY, F. CHAMINADE, Y. CHEN, J. GODET, B. RENE, J.L. DARLIX, Y. MELY, O. MAUFFRET, & P. FOSSE. Structural determinants of TAR RNA-DNA annealing in the absence and presence of HIV-1 nucleocapsid protein. Nucleic Acids Res., 2011, 39, 8148-8162. IF=7.8.

166. V. GREINER, V. SHVADCHAK, Y. ARNTZ, J FRITZ, P. DIDIER, B. FRISCH, C. BOUDIER, Y. MELY, & H. DE ROCQUIGNY. Characterization of the mechanisms of Vpr(52-96) internalization in cells. Biochimie, 2011, 93, 1647-58. IF=3.2.

165.  J. GODET, N. RAMALANJAONA, K.K. SHARMA, L. RICHERT, H. de ROCQUIGNY, J.L. DARLIX, G. DUPORTAIL, & Y. MELY. Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the Primer Binding Site complementary sequences during the obligatory plus strand transfer. Nucleic Acids Res., 2011, 39, 6633-6645. IF=7.8.

164.  J.L. DARLIX, J. GODET, R. IVANYI-NAGY, P. FOSSE, O. MAUFFRET, & Y. MELY. Flexible nature and specific functions of the HIV-1 Nucleocapsid protein. J. Mol. Biol. 2011, 410, 565-81. IF=4.3

163.  B. GRIGOROV, A. BOCQUIN, C. GABUS, S. AVILOV, Y. MELY, A. AGOPIAN, G. DIVITA, M. GOTTIKH, M. WITVROUW, & J.L. DARLIX. Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription. Nucleic Acids Res., 2011, 39, 5586-96. IF=7.8.

162. R. V. RODIK, A.S. KLYMCHENKO, N. JAIN, S.I. MIROSHNICHENKO, L. RICHERT, V.I. KALCHENKO, & Y. MELY. Virus-sized DNA nanoparticles for gene delivery based on micelles of cationic calixarenes. Chem. Eur. J. 2011, 17, 5526-5538. IF =5.48.

161.  N. ROCHEL, F. CIESIELSKI, J. GODET, E. MOMAN, M. ROESSLE, C. PELUSO-ILTIS, M. MOULIN, M. HAERTLEIN, P. CALLOW, Y. MELY, D.I. SVERGUN & D. MORAS. Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat. Struct. Mol. Biol. 2011, 18, 564-570 ;  IF=12.3.

160.  E. CONTAL, A. KLYMCHENKO, Y. MELY, S. MEUNIER, & A. WAGNER. Core functionalization of polydiacetylene micelles by « click » reaction. Soft matter, 2011, 7, 1648-1650. IF=5.4

159.  O. ZAMOTAIEV, V. POSTUPALENKO, V. SHVADCHAK, V. PIVOVARENKO, A. KLYMCHENKO, & Y. MELY. Improved hydration-sensitive dual-fluorescence labels for monitoring peptide-DNA interactions. Bioconjug. Chem. 2011, 22, 101-107. IF=4.8.

158.  A. BAZZI, L. ZARGARIAN, F. CHAMINADE, C. BOUDIER, H. de ROCQUIGNY, B. RENE, Y. MELY, P. FOSSE, & O. MAUFFRET. Structural insights into the cTAR DNA recognition by the HIV-1 Nucleocapsid protein : role of sugar deoxyriboses in the binding polarity of NC. Nucleic Acids Res, 2011, 39, 3903-3916. IF=7.8.

157.  S. LECAT, M. OUEDRAOGO, T. CHERRIER, F. NOULET, P. RONDE, N. GLASSER, J.L. GALZI, Y. MELY, K. TAKEDA, & B. BUCHER. Contribution of a tyrosine-based motif to cellular trafficking of wild type and truncated NPY Y1 receptors. Cell Signal. 2011, 23, 228-238. IF=4.1.

156.  A. PERRINO, A. KLYMCHENKO, A. MORERE, E CONTAL, A RAMEAU, J.M. GUENET, Y MELY, & A. WAGNER. Insight into the structure and behaviour of polydiacetylene-based micelles. Macromol. Chem. Phys., 2011, 212, 111-117. IF=2.6.

155.  V. Y. POSTUPALENKO, V. V. SHVADCHAK, G. DUPORTAIL, V. G. PIVOVARENKO, A. S. KLYMCHENKO, & Y. MELY. Monitoring membrane binding and insertion of peptides by two-color fluorescent label. Biochim Biophys Acta- Biomembranes, 2011, 1808, 424-32. IF = 4.4.

154. Y. SATO, N. RAMALANJAONA, T. HUET, N. POTIER, J. OSZ, P. ANTONY, C. PELUSO-ILTIS, P. POUSSIN-COURMONTAGNE, E. ENNIFAR, Y. MELY, A. DEJAEGERE, D. MORAS, & N. ROCHEL. The “Phantom Effect” of the Rexinoid LG100754 : Structural and Functional Insights. PLoS ONE 2010, 5, e15119. IF=4.4

153.  N. JAIN, Y. ARNTZ, V. GOLDSCHMIDT, G. DUPORTAIL, Y. MELY, & A.S. KLYMCHENKO. New unsymmetrical bolaamphiphiles : synthesis, assembly with DNA and application for gene delivery. Bioconjug Chem. 2010, 21, 2110-2118. IF=4.8.

152. J. GODET, & Y. MELY. Biophysical studies of the nucleic acid chaperone properties of the HIV-1 nucleocapsid protein. RNA Biology, 2010, 7, 48-60. IF=5.6.

151. K. AMARI, E. BOUTANT, C. HOFMANN, C. SCHMITT-KEICHINGER, L. FERNANDEZ-CALVINO, P. DIDIER, A. LERICH, J. MUTTERER, C. THOMAS, Y. MELY, A. MAULE, & C. RITZENTHALER. Plasmodesmal proteins with receptor-like properties for plant viral movement proteins. Plos Pathogens. 2010., 6, e1001119 (10 pages) IF = 9.7. Cited in the Faculty of 1000 Biology.

150. J.V. FRITZ, L. BRIANT, Y. MELY, S. BOUAZIZ, & H. de ROCQUIGNY. HIV-1 Viral Protein R : from structure to function. Future Virology. 2010, 5, 607-625. IF=0.7.

149.  C. BOUDIER, R. STORCHAK, K.K. SHARMA, P. DIDIER, A. FOLLENIUS-WUND, S. MULLER, J.-L. DARLIX and Y. MELY. Investigating the annealing activity of the HIV-1 trans-activator of transcription TAT. J. Mol. Biol., 2010, 400, 487-501. IF = 4.3.

148.  V.J. GREINER, C. EGELE, S. ONCUL, F. RONZON, C. MANIN, A. KLYMCHENKO, & Y. MELY. Characterization of the lipid and protein organization in HBsAg viral particles by steady-state and time resolved fluorescence spectroscopy. Biochimie, 2010, 92, 994-1002. IF=3.5.

147. Y. ROCHE, A.S. KLYMCHENKO, P. GERBEAU-PISSOT, P. GERVAIS, Y. MELY, F. SIMON-PLAS, & J.M. CORNET. Behavior of Plant Plasma Membranes under Hydrostatic Pressure as Monitored by Fluorescent Environment-Sensitive Probes. Biochem. Biophys. Acta-Biomembranes, 2010, 1798, 1601–1607. IF = 4.4.

146. F. BOLZE, A. NIEL, M. HEILEIN, N. MJDASIRI, J.L. REHSPRINGER, N. SCHAEFFER, P. DIDIER, Y. ARNTZ, Y. MÉLY, & J.F. NICOUD. Two-photon excitation in life sciences : from observation to action. Nonlinear Optics Quantum Optics, 2010, 40, 253–265.

145. L. CHOULIER, V.V. SHVADCHAK, A. NAIDOOA, A.S. KLYMCHENKO, Y. MELY, & D. ALTSCHUH. A peptide-based fluorescent ratiometric sensor for quantitative detection of proteins. Anal Biochem., 2010, 401, 188-195. IF=3.3.

144.  O.A. KUCHERAK, S. ONCUL, D. ZEINAB, D.A. YUSHCHENKO, Y. ARNTZ, P.DIDIER, Y. MELY, & A.S. KLYMCHENKO. Switchable Nile Red-based probe for cholesterol and lipid order at the outer leaflet of biomembranes. J Am. Chem. Soc., 2010, 132, 4907-16. IF=8.8

143.  K.K. SHARMA, P. DIDIER, J.L. DARLIX, H. de ROCQUIGNY, H. BENSIKADDOUR, J.P. LAVERGNE, F. PENIN, J.M. LESSINGER, & Y. MELY. Kinetic analysis of the nucleic acid chaperone activity of the Hepatitis C- Virus core protein. Nucleic Acids Res, 2010, 38, 3632-3642. IF=7.3

142.  V. GOLDSCHMIDT, L.M. MILLER JENKINS, H. DE ROCQUIGNY, J.L. DARLIX, & Y. MELY. The nucleocapsid protein of HIV-1 as a promising therapeutic target for antiviral drugs. HIV therapy, 2010, 4, 179-198.

141.  S. ONCUL, A.S. KLYMCHENKO, O.A. KUCHERAK, A.P. DEMCHENKO, S. MARTIN, M. DONTENWILL, Y. ARNTZ, P. DIDIER, G. DUPORTAIL & Y. MELY. Liquid ordered phase in cell membranes evidenced by a hydration-sensitive probe : effects of cholesterol depletion and apoptosis. Biochim. Biophys. ActaBiomembranes 2010 ; 1798, 1436-1443. IF=4.3.

140. A. KULAKOWSKA, P. JURKIEWICZ, J. SYKORA, A. BENDA, Y. MELY, & M. HOF. Fluorescence Lifetime Tuning-A Novel Approach to Study Flip-Flop Kinetics in Supported Phospholipid Bilayers. J. Fluorescence, 2010, 20, 563-9. IF =2.5.

139.  O.A. KUCHERAK, P. DIDIER, Y. MELY, & A.S. KLYMCHENKO. Fluorene Analogues of Prodan with Superior Fluorescence Brightness and Solvatochromism. J Phys Chem Lett, 2010, , 616-620. IF=6.2.

138. C. PANNECOUQUE, B. SZAFAROWICZ, N. VOLKOVA, V. BAKULEV, W. DEHAEN, Y. MELY, & D. DAELEMANS. Inhibition of the HIV-1 replication by a bis-thiadiazolbenzene-1,2-diamine that chelates the zinc ions from the retroviral nucleocapsid zinc fingers. Antimicrob Agents Chemother, 2010, 54, 1461-1468. IF=4.8.

137. E. BOUTANT, P. DIDIER, A. NIEHL, Y. MELY, C. RITZENTHALER, & M. HEINLEIN. Fluorescent protein recruitment for demonstration and analysis of in vivo protein interactions. Plant J., 2010, 62, 171-177. IF=6.95.

136. J.V. FRITZ, D. DUJARDIN, P. DIDIER, J. DE MEY, J. L. DARLIX, Y. MELY, & H. DE ROCQUIGNY. HIV-1 Vpr oligomerization but not that of Gag directs the interaction between Vpr and Gag. J. Virol., 2010, 84, 1585-1596. IF=5.1.

135. P. CLAUDON, A. VIOLETTE, K. LAMOUR, M. DECOSSAS, S. FOURNEL, B. HEURTAULT, J. GODET, Y. MELY, B. JAMART-GREGOIRE, M.C. AVERLANT-PETIT, J.P. BRIAND, G. DUPORTAIL, H. MONTEIL, & G. GUICHARD. Consequences of Isostructural Main Chain Modifications for the Design of Antimicrobial Foldamers : Helical Mimics of Host-defense Peptides Based on Heterogeneous Amide/Urea Backbone. Angew. Chem. Int. Ed. Engl., 2010, 49, 333-336. IF=11.25

134.  R. DAS, A.S. KLYMCHENKO, G. DUPORTAIL, & Y. MELY. An unusually slow proton transfer dynamics of a 3-hydroxychromone dye in protic solvents. Photochem. Photobiol. Sci., 2009, 8:1583-1589. IF=2.45.

133. A. HAYEK, F. BOLZE, C. BOURGOGNE, P.L. BALDECK, P. DIDIER, Y. ARNTZ, Y. MÉLY, & J.F. NICOUD. Boron containing two-photon absorbing chromophores. 2. Fine tuning of the one- and two-photon photophysical properties of pyrazabole based fluorescent bio-probes. Inorg. Chem., 2009, 48, 9112-9119. IF=4.2.

132. P. DIDIER, G ULRICH, Y. MELY, & R. ZIESSEL. Improved Push-Pull-Push E-Bodipy Fluorophores for Two-photon Cell-Imaging. Org. Biomol. Chem., 2009, 7, 3639-3942. IF=3.55.

131.  M. SPADAFORA, V.Y. POSTUPALENKO, V.V. SHVADCHAK, A.S. KLYMCHENKO, Y. MELY, A. BURGER, & R. BENHIDA. Synthesis of Ratiometric Fluorescent Nucleosides Featuring 3-Hydroxychromone Nucleobases. Tetrahedron, 2009, 65, 7809-7816. IF=2.9.

130.  B. ILIEN, N. GLASSER, J.P. CLAMME, P. DIDIER, E. PIEMONT, R. CHINNAPAN, S. DAVAL, J.L. GALZI, & Y. MELY. Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process. J Biol Chem, 2009, 284, 19533-19543. IF=5.7.

129.  M.D. BILOKIN, V.V. SHVADCHAK, D.A. YUSHCHENKO, A.S. KLYMCHENKO, G. DUPORTAIL, Y. MELY, & V.G. PIVOVARENKO. 3-Hydroxybenzo[g]quinolones : dyes with red-shifted absorption and highly resolved dual emission. Tetrahedron Lett., 2009, 50, 4714-4719. IF=2.6.

128  V. SHVADCHAK, S. SANGLIER, S. ROCLE, P. VILLA, J. HAIECH, M. HIBERT, A. VAN DORSSELAER, J.J. BOURGUIGNON, Y. MELY, & H. DE ROCQUIGNY. Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein. Biochimie, 2009, 91, 916-923. IF=3.2

127. C. BOUDIER, A.S. KLYMCHENKO, Y. MELY, & A. FOLLENIUS-WUND. Local environment perturbations in alpha1-antitrypsin monitored by a ratiometric fluorescent label. Photochem. Photobiol. Sci., 2009, 8, 814-821, IF=2.3.

126.  A.P. DEMCHENKO, Y. MELY, G. DUPORTAIL, & A.S. KLYMCHENKO. Monitoring Biophysical Properties of Lipid Membranes by Environment-Sensitive Fluorescent Probes. Biophys J, 2009, 96, 3461-3470. IF=4.8

125.  S.V. AVILOV, J. GODET, E. PIEMONT, & Y. MELY. Site-specific characterization of HIV-1 nucleocapsid protein binding to oligonucleotides with two binding sites. Biochemistry, 2009, 48, 2422–2430. IF=3.8

124.  V.V. SHVADCHAK, A.S. KLYMCHENKO, H. de ROCQUIGNY & Y. MELY. Sensing peptide-oligonucleotide interactions by a two-color environment-sensitive label : application to the HIV-1 nucleocapsid protein. Nucleic Acids Res, 2009, 37, e25. IF=7.0 Cited in the Faculty of 1000 Biology.

123.  M.D. BILOKIN, V.V. SHVADCHAK, D.A. YUSHCHENKO, G. DUPORTAIL, Y. MELY, & V.G. PIVOVARENKO. Dual-Fluorescence Probe of Environment Basicity (Hydrogen Bond Accepting Ability) Displaying no Sensitivity to Polarity. J. Fluoresc., 2009, 19, 545-553. IF=2.2

122. A.S. KLYMCHENKO, S. ONCUL, P. DIDIER, E. SCHAUB, L. BAGATOLLI, G. DUPORTAIL, & Y. MELY. Visualization of lipid domains in giant unilamellar vesicles using an environment-sensitive membrane probe based on 3-hydroxyflavone. Biochem. Biophys. Acta, Biomembranes, 2009, 1788, 495-499. IF=3.8

121.  P. DIDIER, J. GODET, & Y. MELY. Two-photon two-focus fluorescence correlation spectroscopy (2fFCS) with a tunable distance between the excitation volumes. J. Fluorescence, 2009, 19, 561-565. IF=2.2

120. C. HALUSKA, A. SCHRODER, P. DIDIER, D. HEISSLER, G. DUPORTAIL, Y. MELY,  & C. M. MARQUES. Combining Fluorescence Lifetime and Polarization Microscopy to Discriminate Phase Separated Domains in Giant Unilamellar Vesicles. Biophys. J., 2008, 95, 5737-5747. IF=4.8

119.  D. GROHMANN, J. GODET, Y. MELY, J.L. DARLIX, and T. RESTLE. HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates. Biochemistry, 2008, 47, 12230-12240. IF=3.4

118. J.V. FRITZ, P. DIDIER, J.P. CLAMME, E. SCHAUB, D. MURIAUX, C. CABANNE, N. MORELLET, S. BOUAZIZ, J.L. DARLIX, Y. MELY, & H. de ROCQUIGNY. Evidences for direct interactions between HIV-1 Vpr molecules in living cells by two photon Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging. Retrovirology, 2008, 5, 87. IF = 4.0

117.  S. BOURBIGOT, N. RAMALANJAONA, C. BOUDIER, G.F.J. SALGADO, B.P. ROQUES , Y. MELY, S. BOUAZIZ, & N. MORELLET. How the HIV-1 nucleocapsid protein binds and destabilises the (-) primer binding site during reverse transcription. J. Mol. Biol., 2008, 383, 1112-28. IF=4.5

116.  A.S. KLYMCHENKO, V.V. SHVADCHAK, D.A. YUSHCHENKO, N. JAIN & Y. MELY. Excited-state intramolecular proton transfer distinguishes microenvironments in single- and double-stranded DNA. J. Phys. Chem. B., 2008, 112, 12050-12055. IF=4.1

115.  R. DAS, A.S. KLYMCHENKO, G. DUPORTAIL, & Y. MELY. Excited state proton transfer and solvent relaxation of a 3-hydroxyflavone probe in lipid bilayers. J. Phys. Chem. B., 2008, 112, 11929-11935. IF=4.1

114. X. ZHANG, S. ERCELEN, V.E. TIKHONOV, S.Z. KARAEVA, A.V. SLITA, V.V. ZARUBAEV, Y. MELY, G. DUPORTAIL & V.G. BABAK. Alkylated chitosans of low molecular weight as non-viral transfection vectors for gene therapy. Russ. J. Gen. Chem. 78, 1093-1102, 2008. IF=0.5

113.  K. ENANDER, L. CHOULIER, A.L. OLSSON, D.A. YUSHCHENKO, D. KANMERT, A.S. KLYMCHENKO, A.P. DEMCHENKO, Y. MELY, & D. ALTSCHUH. A peptide-based, ratiometric biosensor construct for direct fluorescence detection of a protein analyte. Bioconjugate Chemistry, 2008, 19, 1864-1870. IF=4.4

112.  C. EGELE, P. BARBIER, P. DIDIER, E. PIEMONT, D. ALLEGRO, O. CHALOIN, S. MULLER, V. PEYROT & Y. MELY. Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat. Retrovirology, 2008, 5, 62. IF=4.0

111.  X. ZHANG, K. K. SHARMA, M. BOEGLIN, J. OGIER, J.C. VOEGEL, Y. MELY, and N. JESSEL. Transfection ability and intracellular DNA pathway of nano-structured gene delivery systems. Nano Letters, 2008, 8, 2432-2436. IF=9.6

110. C.A. KENFACK, E. PIEMONT, N. BEN GAIED, A. BURGER, & Y. MELY. Time-resolved fluorescent properties of 8-vinyl-deoxyadenosine and 2-amino-deoxyribosylpurine exhibit different sensitivity to their opposite base in duplexes. J Phys Chem B, 2008, 112, 9736-9745. IF=4.1

109. K. BRANDNER, A. SAMBADE, E. BOUTANT, P. DIDIER, Y. MELY, C. RITZENTHALER, & M. HEINLEIN. Tobacco mosaic virus movement protein interacts with green fluorescent protein-tagged microtubule end-binding protein. Plant Physiology, 2008, 147, 611-623. IF=6.4

108.  G. M’BAYE, Y. MELY, G. DUPORTAIL & A.S. KLYMCHENKO. Liquid ordered and gel phases of lipid bilayers : fluorescent probes reveal close fluidity but different hydration. Biophys J., 2008, 95, 1217-1225. IF=4.8

107.  M. KUCIAK, C. GABUS, R. IVANYI-NAGY, K. SEMRAD, R. STORCHAK, O. CHALOIN, S. MULLER, Y. MELY & J.L. DARLIX. The HIV-1 transcriptional activator Tat has potent nucleic acid chaperoning activities in vitro. Nucleic Acids Res, 2008, 36, 3389-3400. IF=7.0

106.  B. BERKHOUT, R. GORELICK, M. SUMMERS, Y. MELY & J.L. DARLIX. Sixth International symposium on retroviral proteins. Retrovirology. 2008, 5, 21. IF =4.0

105.  X. ZHANG, S. ERCELEN, G. DUPORTAIL, E. SCHAUB, V. TIKHONOV, A. SLITA, V. ZARUBAEV, V. BABAK & Y. MELY. Hydrophobically Modified Low Molecular Weight Chitosans as Efficient and Non-toxic Gene Delivery Vectors. J. Gene Med., 2008, 10, 527-539. IF=3.9

104. J. DIETZ, J. KOCH, A. KAUR, C. RAJA, S. STEIN, M. GREZ, A. PUSTOWKA, S. MENSCH, J. FERNER, R. TEMPE, G. DIVITA, Y. MELY, H. SCHWALBE & U. DIETRICH. Antiviral activity of peptide ligands for the HIV-1 packaging signal y after binding optimization on spot synthesis peptide membranes. ChemMedChem, 2008, 3, 749-55. IF=2.8

103.  H. de ROCQUIGNY, V. SHVADCHAK, S. AVILOV, C.Z. DONG, U. DIETRICH, J.L. DARLIX & Y. MELY. Targeting the retroviral nucleocapsid protein in anti-HIV-1 therapy. Mini Rev. Med. Chem., 2008, 8, 24-35. IF=3.1

102.  S.V. AVILOV, E. PIEMONT, V. SHVADCHAK, H. de ROCQUIGNY & Y. MELY. Probing dynamics of HIV-1 nucleocapsid protein/target hexanucleotide complexes by 2-aminopurine. Nucleic Acids Res., 2008, 36, 885-96. IF=7.0

101.  M. OUEDRAOGO, S. LECAT, M. D. ROCHDI, M. HACHET-HAAS, H. MATTHES, H. GICQUIAUX, S. VERRIER, M. GAIRE, N. GLASSER, Y. MELY, K. TAKEDA, M. BOUVIER, J.L. GALZI & B. BUCHER. Distinct motifs of Neuropeptide Y receptors differentially regulate trafficking and desensitization. Traffic, 2008, 9, 305-24. IF=6.5

100.  D.A. YUSHCHENKO, V.V. SHVADCHAK, A.S. KLYMCHENKO, G. DUPORTAIL, V.G. PIVOVARENKO & Y. MELY. Modulation of Excited State Intramolecular Proton Transfer by Viscosity in Protic Media. J. Phys. Chem. A, 2007, 111, 10435-10438. IF=2.9

099. C. EGELE, E. PIEMONT, P. DIDIER, D. FICHEUX, B. ROQUES, J.L. DARLIX, H. de ROCQUIGNY & Y. MELY. The single-finger nucleocapsid protein of Moloney Murine Leukaemia Virus binds and destabilizes the TAR sequences of HIV-1 but does not promote efficiently their annealing. Biochemistry, 2007, 46, 14650-14662. IF=3.4

098.  N. RAMALANJAONA, H. de ROCQUIGNY, A. MILLET, D. FICHEUX, J.L. DARLIX & Y. MELY. Investigating the mechanism of the nucleocapsid protein-promoted second strand transfer during HIV-1 DNA synthesis. J. Mol. Biol., 2007, 374, 1041-1053. IF=4.5

097.  D.A. YUSHCHENKO, V. SHVADCHAK, A.S. KLYMCHENKO, G. DUPORTAIL, V.G. PIVOVARENKO & Y. MELY. Steric control of the excited state intramolecular proton transfer in 3-hydroxyquinolones : steady-state and time-resolved fluorescence study. J. Phys. Chem A, 2007, 111, 8986-8992. IF=2.9

096.  D.A. YUSHCHENKO, O. B. VADZYUK, S.O. KOSTERIN, G. DUPORTAIL, Y. MELY & V.G. PIVOVARENKO. Sensing of ATP anion in aqueous solutions and mitochondria by a fluorescent 3-hydroxyflavone dye. Anal. Biochem., 2007, 369, 218-225. IF=3.0

095.  A.S. KLYMCHENKO, D.A. YUSHCHENKO & Y. MELY. Tuning excited state intramolecular proton transfer in 3-hydroxyflavone derivative by reaction of its isothiocyanate group with an amine. J. Photochem.Photobiol. A, 2007, 192, 93-97. IF=2.0

094. A. HAYEK, A. GRICHINE, T. HUAULT, C. RICARD, F. BOLZE, B. van der SANDEN, J.C. VIAL, Y. MELY, A. DUPERRAY, P.L. BALDECK & J.F. NICOUD,. Cell-permeant cytoplasmic blue fluorophores optimized for in vivo two-photon microscopy with low-power excitation. Microscopy Research and Technique, 2007, 70, 880-885. IF=2.3

093. E. BOMBARDA, E. GRELL, B.P. ROQUES & Y. MELY. Molecular mechanism of the Zn2+-induced folding of the distal CCHC finger motif of the HIV-1 nucleocapsid protein. Biophys. J., 2007, 93, 208-217. IF=4.8

092.  A.S. KLYMCHENKO, C. KENFACK, G. DUPORTAIL & Y. MELY. Effects of polar protic solvents on the dual emission of 3-hydroxychromones. J. Chem. Sci., 2007, 119, 83-89. IF=1.2

091.  A. HAYEK, S. ERCELEN, X. ZHANG, F. BOLZE, J.F. NICOUD, M.D. BILOKIN, E. SCHAUB, P.L. BALDECK & Y. MELY. Conjugation of a new two-photon fluorophore to polyethyleneimine for gene delivery imaging. Bioconjugate Chem., 2007, 18, 844-851. IF=4.4

090.  V.V. SHYNKAR, A.S. KLYMCHENKO, C. KUNZELMANN, G. DUPORTAIL, C.D. MULLER, A.P. DEMCHENKO, J.M. FREYSSINET & Y. MELY. Fluorescent biomembrane probe for ratiometric apoptosis detection at the plasma membrane. J. Am. Chem. Soc., 2007, 129, 2187-2193. IF=7.9

089.  C. TAHTAOUI, C. THOMAS, F. ROHMER, P. KLOTZ, G. DUPORTAIL, Y. MELY, D. BONNET & M. HIBERT. Convenient method to access new 4,4-dialkoxy- and 4,4-diaryloxy-diaza-s-indacene dyes : synthesis and spectroscopic evaluation. J. Org. Chem., 2007, 72, 269-272. IF=4.0

088.  G. M’BAYE, A.S. KLYMCHENKO, D.A. YUSHCHENKO, V.V. SHVADCHAK, T. OZTURK, Y. MELY & G. DUPORTAIL. Fluorescent dyes undergoing intramolecular proton transfer with improved sensitivity to surface charge in lipid bilayers. Photochem. Photobiol. Sci., 2007, 6, 71-76. IF=2.3

087.  C. KENFACK, A. BURGER & Y. MELY. Excited-State Properties and Transitions of Fluorescent 8-Vinyl Adenosine in DNA. J Phys Chem B, 2006, 110, 26327-26336. IF=4.1

086.  D.A. YUSHCHENKO, V.V. SHVADCHAK, M.D. BILOKIN, A.S. KLYMCHENKO, G. DUPORTAIL, Y. MELY & V.G. PIVOVARENKO. Modulation of dual fluorescence in a 3-hydroxyquinolone dye by perturbation of its intramolecular proton transfer with solvent polarity and basicity. Photochem. Photobiol Sci., 2006, 5, 1038-1044. IF=2.3

085.  S. ERCELEN, X. ZHANG, G. DUPORTAIL, C. GRANFILS, J. DESBRIERES, S. KARAEVA, V. TIKHONOV, Y. MELY & V. BABAK. Physicochemical properties of low molecular weight alkylated chitosans, a new class of potential nonviral vectors for gene delivery. Colloids Surf. B Biointerfaces, 2006, 51, 140-148. IF=2.2

084.  C. RAJA, J. FERNER, U. DIETRICH, S. AVILOV, D. FICHEUX, J.L. DARLIX, H. DE ROCQUIGNY, H. SCHWALBE & Y. MELY. A Trp-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein. Biochemistry, 2006, 45, 9254-9265. IF=3.4

083.  A.S. KLYMCHENKO, H. STOECKEL, K. TAKEDA & Y. MELY. Fluorescent probe based on intramolecular proton transfer for fast ratiometric measurement of cellular transmembrane potential. J. Phys. Chem. B, 2006, 110, 13624-13632. IF=4.1

082.  D.A. YUSHCHENKO, V.V. SHVADCHAK, A.S. KLYMCHENKO, G. DUPORTAIL, Y. MELY & V.G. PIVOVARENKO. 2-Aryl-3-hydroxyquinolones, a new class of dyes with solvent dependent dual emission due to excited state intramolecular proton transfer. New. J. Chem., 2006, 30, 774-781. IF=2.6

081.  J. GODET, H. DE ROCQUIGNY, C. RAJA, N. GLASSER, D. FICHEUX, J.L. DARLIX & Y. MELY. During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem. J. Mol. Biol., 2006, 356, 1180-1192. IF=4.5

080.  D.A. YUSHCHENKO, M.D. BILOKIN, O.V. PIVOVARENKO, G. DUPORTAIL, Y. MELY & V.G. PIVOVARENKO. Synthesis and fluorescence properties of 2-aryl-3-hydroxyquinolones, a new class of dyes displaying dual fluorescence. Tetrahedron Lett., 2006, 47, 905-908.  IF=2.6

079.  A. HAYEK, F. BOLZE, J.F. NICOUD, P.L. BALDECK & Y. MELY. Synthesis and characterization of water-soluble two-photon excited blue fluorescent chromophores for bio-imaging. Photochem. Photobiol. Sci., 2006, 5, 102-106. IF=2.3

078.  G. M’BAYE, V.V. SHYNKAR, A.S. KLYMCHENKO, Y. MELY & G. DUPORTAIL. Membrane dipole potential as measured by ratiometric 3-hydroxyflavone fluorescence probes. Accounting for hydration effects. J. Fluorescence, 2006, 16, 35-42. IF=2.2

077.  C. EGELE, E. SCHAUB, E. PIEMONT, H. DE ROCQUIGNY & Y. MELY. Investigation by fluorescence correlation spectroscopy of the chaperoning interactions of HIV-1 nucleocapsid protein with the viral DNA initiation sequences. C.R. Biol., 2005, 328, 1041-1051. IF=1.6

076.  V.V. SHYNKAR, A.S. KLYMCHENKO, G. DUPORTAIL, A.P. DEMCHENKO & Y. MELY. Two-color fluorescent probes for imaging dipole potential of cell plasma membranes. Biochem. Biophys. Acta. Biomembranes, 2005, 1712, 128-136. IF=3.8

075.  E. BOMBARDA, B.P. ROQUES, Y. MELY & E. GRELL. Mechanism of zinc coordination by point-mutated structures of the distal CCHC binding motif of the HIV-1 NCp7 protein. Biochemistry, 2005, 44, 7315-7325. IF=3.4

074.  H. BELTZ, C. CLAUSS, E. PIEMONT, D. FICHEUX, R.J. GORELICK, B. ROQUES, J.L. DARLIX, H. DE ROCQUIGNY & Y. MELY. Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization. J. Mol. Biol., 2005, 348, 1113-1126. IF=4.5

073.  N. BEN GAIED, N. GLASSER, N. RAMALANJAONA, H. BELTZ, P. WOLFF, R. MARQUET, A. BURGER & Y. MELY. 8-vinyl-deoxyadenosine, an alternative fluorescent nucleoside analogue to 2’-deoxyribosyl-2-aminopurine with improved properties. Nucleic Acids Res., 2005, 33, 1031-1039. IF=7.0 Cited in the Faculty of 1000 Biology.

072.  S. BOURBIGOT, H. BELTZ, J. DENIS, N. MORELLET, B.P. ROQUES, Y. MELY & S. BOUAZIZ. The C-Terminal domain of Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain. Biochem. J., 2005, 387, 333-341. IF=4.0

071.  S. ERCELEN, A.S. KLYMCHENKO, Y. MELY & A.P. DEMCHENKO. The binding of novel two-color fluorescence probe FA to serum albumins of different species. Int. J. Biol. Macromol., 2005, 35, 231-242. IF=2.0

070.  V.V. SHYNKAR, A.S. KLYMCHENKO, Y. MELY, G. DUPORTAIL & V.G. PIVOVARENKO. Anion formation of 4’-dimethylamino-3-hydroxyflavone in phosphatidylglycerol vesicles induced by HEPES buffer : a steady-state and time-resolved fluorescence investigation. J. Phys. Chem. B, 2004, 108, 18750-18755. IF=4.1

069.  A.S. KLYMCHENKO & Y. MELY. 7-(2-Methoxycarbonylvinyl)-3-hydroxychromones : new dyes with red shifted dual emission. Tetrahedron Lett., 2004, 45, 8391-8394. IF=2.6

068.  V. SHYNKAR, A.S. KLYMCHENKO, E. PIEMONT, A.P. DEMCHENKO & Y. MELY. Dynamics of intermolecular hydrogen bonds in the excited states of 4’-dialkylamino-3-hydroxyflavones. On the pathway to ideal fluorescent hydrogen bonding sensor. J. Phys. Chem. A, 2004, 108, 8151-8159. IF=2.9

067.  C. EGELE, E. SCHAUB, N. RAMALANJAONA, E. PIEMONT, D. FICHEUX, B. ROQUES, J. L. DARLIX & Y. MELY. HIV-1 nucleocapsid protein binds to the viral initiation DNA sequences and chaperones their kissing interactions. J. Mol. Biol., 2004, 342, 453-466. IF=4.5

066.  A. KLYMCHENKO, Y MELY, A. DEMCHENKO & G. DUPORTAIL. Simultaneous probing of hydration and polarity of lipid bilayers with 3-hydroxyflavone fluorescent dyes. Biochim. Biophys. Acta Biomembranes, 2004, 1665, 6-19. IF=3.8

065.  R.H. STOTE, E. KELLENBERGER, H. MULLER, E. BOMBARDA, B. ROQUES, B. KIEFFER & Y. MELY. Structure of the His44®Ala single point mutant of the distal finger motif of HIV-1 nucleocapsid protein : a combined NMR, molecular dynamics simulation and fluorescence study. Biochemistry, 2004, 43, 7687-7697. IF=3.4

064.  H. BELTZ, E. PIEMONT, E. SCHAUB, D. FICHEUX, B. ROQUES, J. L. DARLIX & Y. MELY. Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7. J. Mol. Biol., 2004, 338, 711-723. IF=4.5

063.  A. KLYMCHENKO, G. DUPORTAIL, A. DEMCHENKO & Y. MELY. Bimodal distribution and fluorescence response of environment-sensitive probes in lipid bilayers Biophys. J., 2004, 86, 2929-2941. IF=4.8

062.  D. LLERES, J.M. WEIBEL, D. HEISSLER, G. ZUBER, G. DUPORTAIL & Y. MELY. Dependence of the cellular internalization and transfection efficiency on the structure and physicochemical properties of cationic detergent/DNA/liposomes. J. Gene Med., 2004, 6, 415-428. IF=3.7

061.  D. LLERES, J.P. CLAMME, E. DAUTY, J.P. BEHR, Y. MELY & G. DUPORTAIL. Oxidizable cationic detergent for gene therapy : Condensation of DNA and interaction with model membranes. Progr. Coll. Polymer Sci., 2004, 123, 61-64. Non indexé.

060.  J.P. CLAMME, G. KRISHNAMOORTHY & Y. MELY. Intracellular dynamics of the gene delivery vehicle polyethylenimine during transfection : investigation by two photon fluorescence correlation spectroscopy. Biochim. Biophys. Acta, 2003, 1617, 52-61. IF=3.8

059.  V. SHYNKAR, Y. MELY, G. DUPORTAIL, A. KLYMCHENKO & A. DEMCHENKO. Picosecond time-resolved fluorescence studies are consistent with reversible excited-state intramolecular proton transfer in 4’-dialkylamino-3-hydroxyflavones. J. Phys. Chem. A., 2003, 107, 9522-9529. IF=2.9

058.  P. RAMOS, T. COSTE, E. PIEMONT, J.M. LESSINGER, J.A. BOUSQUET, C. CHAPUS, B. KERFELEC, G. FERARD & Y. MELY. Time-resolved fluorescence allows to selectively monitor Trp30 environmental changes in the seven-Trp-containing human pancreatic lipase. Biochemistry, 2003, 42, 12488-14496. IF=3.4

057.  E. PION, E. BOMBARDA, P. STIEGLER, G.M. UHLMANN, Y. MELY, G. DE MURCIA & D. GERARD. Poly (ADP-ribose) polymerase-1 (PARP-1) dimerizes at a 5’ recessed DNA end in vitro : a fluorescence study. Biochemistry, 2003, 42, 12409-12417. IF=3.4

056.  G. KRISHNAMOORTHY, B.P. ROQUES, J.L. DARLIX & Y. MELY. DNA condensation by the nucleocapsid protein of HIV-1 : a mechanism for ensuring DNA protection. Nucleic Acids Res., 2003, 31, 5425-5432. IF=7.0

055.  A. KLYMCHENKO, G. DUPORTAIL, Y. MELY & A. DEMCHENKO. Ultrasensitive two-color fluorescence probes for dipole potential in phospholipid membranes. Proc. Natl. Acad. Sci. USA, 2003, 100, 11219-11224. IF=10.4. Cited in the Faculty of 1000 Biology.

054.  A. IRA, Y. MELY & G. KRISHNAMOORTHY. Cell viability during polyethleneimine-assisted transfection probed by time-resolved fluorescence microscopy. J. Fluorescence, 2003, 13, 339-347. IF=2.2

053.  J.L. DARLIX, M. LOPEZ LASTRA, Y. MELY & B. ROQUES. Nucleocapsid protein chaperoning of nucleic acids at the heart of HIV structure, assembly and proviral DNA synthesis. HIV sequence Compendium, 2002, 69-88. Non indexé

052.  A. DEMCHENKO, A. KLYMCHENKO, V.G. PIVOVARENKO, S. ERCELEN, G. DUPORTAIL & Y. MELY. Multiparametric color-changing fluorescence probes. J. Fluorescence, 2003, 13, 291-296. IF=2.2

051.  H. BELTZ, J. AZOULAY, S. BERNACCHI, J.P. CLAMME, D. FICHEUX, B.P. ROQUES, J.L. DARLIX & Y. MELY. Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7. J. Mol. Biol., 2003, 328, 95-108. IF=4.5

050.  J.P. CLAMME, J. AZOULAY & Y. MELY. Monitoring of the formation and dissociation of polyethyleneimine/DNA complexes by two photon fluorescence correlation spectroscopy. Biophys J., 2003, 84, 1960-1968. IF=4.8

049.  J.A. BOUSQUET, J. DURANTON, Y. MELY & J.G. BIETH. Conformational change in porcine pancreatic elastase following complexation with a1-antitrypsin : a circular dichroism investigation. Biochem. J., 2003, 370, 345-349. IF=4.0

048.  J. AZOULAY, J.P. CLAMME, J.L. DARLIX, B.P. ROQUES & Y. MELY. Destabilization of the HIV-1 TAR structure by the nucleocapsid protein through activation of conformational fluctuations. J.Mol.Biol., 2003, 362, 691-700. IF=4.5

047.  S. BERNACCHI, E. PIEMONT, N. POTIER, A. VAN DORSSELAER & Y. MELY. Excitonic heterodimer formation in an HIV-1 oligonucleotide labeled with a donor-acceptor pair used for florescence resonance energy transfer. Biophys. J., 2003, 84, 643-654. IF=4.8

046.  H.M. COURRIER, M.P. KRAFFT, N. BUTZ, C. PORTE, N. FROSSARD, A. REMY-KRISTENSEN, Y. MELY, F. PONS & T.F. VANDAMME. Evaluation of cytotoxicity of new semi-fluorinated amphiphiles derived from dimorpholinophosphate. Biomaterials, 2003, 24, 689-696. IF=6.4

045.  G. KRISHNAMOORTHY, G. DUPORTAIL & Y. MELY. Structure and dynamics of condensed DNA probed by 1,1’-(4,4,8,8-Tetramethyl-4,8-diazaundecamethylene)bis[4-[[3-methylbenz-1,3-oxazol-2-yl]methylidine]-1,4-dihydroquinolinium]Tetraiodide Fluorescence. Biochemistry, 2002, 41, 15277-15287. IF=3.4

044.  A. KLYMCHENKO, G. DUPORTAIL, T. OZTURK, V. PIVOVARENKO, Y. MELY & A. DEMCHENKO. Novel two-band ratiometric fluorescence probes with different location and orientation in phospholipid membranes. Chem. Biol., 2002, 9, 1199-1208. IF=6.2

043.  S. LECAT, B. BUCHER, Y. MELY & J.L. GALZI. Mutations in the extracellular amino-terminal domain of the NK2 neurokinin receptor abolish cAMP signaling but preserve intracellular calcium responses. J. Biol. Chem. 2002, 277, 42034-42048. IF=5.7

042.  P. MELLET, Y. MELY, L. HEDSTROM, N. SRIVIDYA, D. BELORGEY, H. RUBIN & J.G. Bieth. Comparative trajectories of active and inactive trypsin upon binding to serpins. J Biol. Chem., 2002, 277, 38901-38914. IF=5.7

041.  D. LlEres, J.P. Clamme, E. Dauty, T. Blessing, G. Krishnamoorthy, G. Duportail & Y. MEly. Investigation of the stability of dimeric cationic surfactant/DNA complexes and their interaction with model membrane systems. Langmuir, 2002, 18, 10340-10347. IF=4.2

040.  G. DUPORTAIL, A. KLYMCHENKO, Y. MELY & A.P. DEMCHENKO. On the coupling between surface charge and hydration in biomembranes. Experiments with 3-hydroxyflavone probes. J. Fluorescence, 2002, 12, 181-185. IF=2.2

039.  E. BOMBARDA, H. CHERRADI, N. MORELLET, B.P. ROQUES & Y. MELY. Zn2+ binding properties of single point mutants of the C-terminal zinc finger of HIV-1 nucleocapsid protein : evidence of a critical role of cysteine 49 in Zn2+-dissociation. Biochemistry, 2002, 41, 4312-4320. IF=3.4

038. S. BERNACCHI, S. STOYLOV, E. PIEMONT, D. FICHEUX, B.P. ROQUES, J.L. DARLIX & Y. MELY. HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence. J. Mol. Biol., 2002, 317, 385-399. IF=4.5

037.  S. RAMBOARINA, N. SRIVIDYA, R.A. ATKINSON, N. MORELLET, B.P. ROQUES, J.F. LEFEVRE, Y. MELY & B. KIEFFER. Effects of temperature on the dynamic behaviour of the HIV-1 nucleocapsid NCp7 and its DNA complex. J. Mol. Biol., 2002, 316, 611-627. IF=4.5

036.  H. Gicquiaux, M. Gaire, S. LECAT, A. DIETERLEN, Y. MELY, K. TAKEDA, B. BUCHER & J.L. GALZI. Rapid internalization and recycling of the human neuropeptide Y Y1 receptor. J. Biol. Chem., 2002, 277, 6645-6655. IF=5.7

035. A. REMY-KRISTENSEN, J.P. CLAMME, C. VUILLEUMIER, J.G. KUHRY & Y. MELY. Role of endocytosis in the transfection of L929 fibroblasts by PEI/DNA complexes. Biochim. Biophys. Acta, 2001, 1514, 21-32. IF=3.8

034. D. LLERES, E. DAUTY, J.P. BEHR, Y. MELY & G. DUPORTAIL. DNA condensation by an oxidizable cationic detergent. Interactions with lipid vesicles. Chem. Phys. Lipids, 2001, 111, 59-71. IF=2.7

033. G. DUPORTAIL, A. KLYMCHENKO, Y. MELY & A. DEMCHENKO. Neutral fluorescence probe with strong ratiometric response to surface charge of phospholipid membranes. FEBS Letters, 2001, 508, 196-200. IF=3.3

032. E. BOMBARDA, N. MORELLET, H. CHERRADI, B. SPIESS, S. BOUAZIZ, E. GRELL, B.P. ROQUES & Y. MELY. Determination of the pKa of the four Zn(2+)-coordinating residues of the distal finger motif of the HIV-1 nucleocapsid protein : consequences on the binding of Zn(2+). J. Mol. Biol., 2001, 310, 659-672. IF=4.5

031. S. BERNACCHI & Y. MELY. Exciton interaction in molecular beacons : a sensitive sensor for short-range modifications of the nucleic acid structure. Nucl. Acids Res., 2001, 29, e62. IF=7.0

030. J.A. BOUSQUET, C. GARBAY, B.P. ROQUES & Y. MEly. A CD investigation of the native and non-native conformational states of the Grb2 N-terminal SH3 domain. Effect of binding to a Proline-rich peptide from Sos. Biochemistry, 2000, 39, 7722-7735. IF=3.4

029. J.P. CLAMME, S. BERNACCHI, C. VUILLEUMIER, G. DUPORTAIL & Y. Mély. Gene transfer by cationic surfactants is essentially limited by the trapping of the surfactant/DNA complexes onto the cell membrane : a fluorescence investigation. Biochem. Biophys. Acta, 2000, 1467, 347-361. IF=3.8

028. C. Vuilleumier, E. Bombarda, N. Morellet, D. Gérard, B.P. Roques & Y. Mély. Nucleic acid sequence discrimination by the HIV-1 nucleocapsid protein NCp7 : a fluorescence study. Biochemistry, 1999, 38, 16816-16825. IF=3.4

027. E. BOMBARDA, A. ABABOU, C. VUILLEUMIER, D. GERARD, B.P. ROQUES, E. PIEMONT & Y. MELY. Time-resolved fluorescence investigation of the HIV-1 nucleocapsid protein : influence of the binding of nucleic acids. Biophys. J., 1999, 76, 1561-1570. IF=4.8

026. S.P. STOYLOV, E. STOYLOVA, R TODOROV, P. SCHMIEDEL, C. THUNIG, H. HOFFMANN, B.P. ROQUES, E. LE CAM, D. COULAUD, E. DELAIN, D GERARD & Y. MELY. Aggregation of polyA/HIV-1 nucleocapsid protein NCp7 complexes : mechanism and aggregate properties. Colloids Surf. B, 1999, 152, 263-274. IF=2.1

025. P. MELLET, C. BOUDIER, Y. MELY & J.G. BIETH. Stopped-flow fluorescence energy transfer measurement of the rate constants describing the reversible formation and the irreversible rearrangement of the elastase-a1-proteinase inhibitor complex. J. Biol. Chem., 1998, 273, 9119-9123. IF=5.7

024. C. SCOTTO, Y. MELY, H. OHSHIMA, J. GARIN, C. COCHET, E. CHAMBAZ & J. BAUDIER. Cysteine oxidation in the mitogenic S100b protein leads to changes in phosphorylation by catalytic CKII- a subunit. J. Biol. Chem., 1998, 273, 3901-3908. IF=5.7

023. E. LE CAM, D. COULAUD, E. DELAIN, B.P. ROQUES, D. GERARD, E. STOYLOVA, C. VUILLEUMIER, S.P. STOYLOV & Y. MELY. Properties and growth mechanism of the ordered aggregation of a model RNA by the HIV-1 nucleocapsid protein  : an electron microscopy investigation. Biopolymers, 1998, 45, 217-229. IF=2.6

022. Y. MELY, M. CADENE, I. SYLTE & J. BIETH. Mapping the suramin-binding sites of human neutrophile elastase : investigation by fluorescence resonance energy transfer and molecular modeling. Biochemistry, 1997, 36, 15624-15631. IF=3.4

021. S. STOYLOV, C. VUILLEUMIER, E. STOYLOVA, B.P. ROQUES, D. GERARD & Y. MELY. Ordered aggregation of ribonucleic acids by the HIV-1 nucleocapsid protein. Biopolymers, 1997, 41, 301-312. IF=2.6

020. C. VUILLEUMIER, C. MAECHLING-STRASSER, D. GERARD & Y. MELY. Evidence and prevention of HIV-1 nucleocapsid protein adsorption onto fluorescence quartz cells. Anal. Biochemistry, 1997, 244, 183-185. IF=3.4

019. Y. MELY, H. DE ROCQUIGNY, N. MORELLET, B.P. ROQUES & D. GERARD. Zinc-binding to the HIV-1 nucleocapsid protein : a thermodynamic investigation by fluorescence spectroscopy. Biochemistry, 1996, 35, 5175-5182. IF=3.4

018.  D. ILLINGER, G. DUPORTAIL, Y. MELY, N. POIREL-MORALES, D. GERARD & J.G. KUHRY. A comparison of the fluorescence properties of TMA-DPH as a probe for plasma membrane and for endocytic membrane. Biochim. Biophys. Acta, 1995, 1239, 58-66. IF=3.8

017. Y. MELY, H. DE ROCQUIGNY, M. SORINAS-JIMENO, G. KEITH, B.P. ROQUES, R. MARQUET & D. GERARD. Binding of the HIV-1 nucleocapsid protein to the primer tRNALys,3, in vitro, is essentially not specific. J. Biol. Chem., 1995, 270, 1650-1656. IF=5.7

016.  Y. MELY, N. JULLIAN, N. MORELLET, H. DE ROCQUIGNY, C.Z. DONG, E. PIEMONT, B.P. ROQUES & D. GERARD. Spatial proximity of the HIV-1 nucleocapsid protein zinc fingers investigated by time-resolved fluorescence and fluorescence resonance energy transfer. Biochemistry, 1994, 33, 12085-12091. IF=3.4

015.  H. DEMENE, C.Z. DONG, M. OTTMANN, M.C. ROUYEZ, N. JULLIAN, N. MORELLET, Y. MELY, J.L. DARLIX, M.C. FOURNIE-ZALUSKI, S. SARAGOSTI & B.P. ROQUES.. 1H NMR structure and biological studies of His23Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity. Biochemistry, 1994, 33, 11707-11716. IF=3.4

014.  N. MORELLET, H. DE ROCQUIGNY, Y. MELY, N. JULLIAN, H. DEMENE, M. OTTMANN, D. GERARD, J.L. DARLIX, M.C. FOURNIE-ZALUSKI & B.P. ROQUES. Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR. J. Mol. Biol., 1994, 235, 287-301. IF=4.5

013.  S. CLERMONT, C. CORBIER, Y. MELY, D. GERARD, A. WONACOTT & G. BRANLANT. Determinants of coenzyme specificity in glyceraldehyde-3-phosphate dehydrogenase : the role of the acidic residue in the fingerprint region of the nucleotide binding fold. Biochemistry, 1993, 32, 10178-10184. IF=3.4

012.  Y. MELY, E. PIEMONT, M. SORINAS-JIMENO, D. GERARD, H. DE ROCQUIGNY, N. JULLIAN, N. MORELLET & B.P. ROQUES. Structural and dynamic characterization of the aromatic amino acids of the HIV-1 nucleocapsid protein zinc fingers and their involvement in the heterologous tRNAPhe binding : a steady-state and time-resolved fluorescence study. Biophys. J., 1993, 65, 1513-1522. IF=4.8

011.  Y. MELY, H. DE ROCQUIGNY, E. PIEMONT, H. DEMENE, N. JULLIAN, M.C. FOURNIE-ZALUSKI, B. ROQUES & D. GERARD. Influence of the N- and C-terminal chains on the zinc-binding and conformational properties of the central zinc finger structure of Moloney murine leukaemia virus nucleocapsid protein : a steady-state and time-resolved fluorescence study. Biophys. Biophys. Acta, 1993, 1161, 6-18. IF=3.8

010.  B. FALLER, Y. MELY, D. GERARD & J.G. BIETH. Heparin-induced conformational change and activation of mucus proteinase inhibitor. Biochemistry, 1992, 31, 8285-8291. IF=3.4

009.  Y. MELY, F. CORNILLE, M.C. FOURNIE-ZALUSKI, J.L. DARLIX, B.P. ROQUES & D. GERARD. Investigation of zinc-binding affinities of Moloney murine leukaemia virus nucleocapsid protein and its related zinc finger and modified peptides. Biopolymers, 1991, 31, 899-906. IF=2.6

008.  C. CORBIER, A. MOUGIN, Y. MELY, H.W. ADOLPH, M. ZEPPEZAUER, D. GERARD, A. WONACOTT & G. BRANLANT. The nicotinamide subsite of glyceraldehyde-3-phosphate dehydrogenase studied by site-directed mutagenesis. Biochimie, 1990, 72, 545-554. IF=3.2

007.  F. CORNILLE, Y. MELY, D. FICHEUX, I. SALVIGNOL, D. GERARD, J.L. DARLIX, M.C. FOURNIE-ZALUSKI & B.P. ROQUES. Solid phase synthesis of the retroviral nucleocapsid protein NCp10 of Moloney murine leukaemia virus and related "zinc-fingers" in free SH forms : influence of zinc chelation on structural and biochemical properties. Int. J. Peptide Protein Res., 1990, 36, 551-558. IF= ?

006.  Y. MELY & D. GERARD. Intra- and interchain disulfide bond generation in S100b protein. J. Neurochem., 1990, 55, 1100-1106. IF=4.5

005.  Y. MELY & D. GERARD. Structural and ion-binding properties of an S100b protein mixed disulfide : comparison with the reappraised native S100b protein properties. ARCh. Biochem. Biophys., 1990, 279, 174-182. IF=2.7

004.  Y. MELY & D. GERARD. Large scale, one-step purification of oxidized and reduced forms of bovine brain S100b protein by HPLC. J. Neurochem., 1988, 50, 739-745. IF=4.5

003.  A. FOLLENIUS-WUND, Y. MELY & D. GERARD. Spectroscopic evidence of two melittin molecules bound to Ca2+-calmodulin. Biochem. Int., 1987, 15, 823-833. IF=2.1

002.  M.C. KILHOFFER, Y. MELY & D. GERARD. The effect of plasma gelsolin on actin filaments. Ca2+-dependency of the capping and severing activities. Biochem. Biophys. Res. Commun., 1985, 131, 1132-1138. IF=2.8

001.  M.G. PALFREYMAN, I.A. MCDONALD, J.R. FOZARD, Y. MELY, A.J. SLEIGHT, M. ZREIKA, J. WAGNER, P. BEY & P.J. LEWIS. Inhibition of monoamine oxidase selectively in brain monoamine nerves using the bioprecursor (E)-ß-fluoromethylene-m-tyrosine (MDL 72394), a substrate for aromatic L-amino acid decarboxylase. J. Neurochem., 1985, 45, 1850-1860. IF=4.5