Laboratoire de Biophotonique et Pharmacologie


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Professeur (PRCE2) UNISTRA

Directeur d'unité

Equipe Biophotonique des interactions moléculaires et cellulaires

Bureau/Salle : E10-E026

Telephone :(+33) +33 (0) 3 68 85 42 63

Courriel : yves.mely


Diplomas and career

Doctor in Pharmacy, 1984 (major), DEA de Pharmacologie, 1985 (major) Doctor in Biophysics, University Louis Pasteur, Strasbourg, 1988. Support from a government fellowship. Military service 1988-89 in a Hospital in Fribourg. Habilitation (Habilitation à diriger des recherches), 1996. Professor Assistant in Biophysics, Faculty of Pharmacy, Strasbourg, 1989. Post doctoral training (1997) with the support of a von Humboldt fellowship in the Max Planck Institute of Biophysics, Frankfurt, Germany Professor of Biophysics, Faculty of Pharmacy, Strasbourg, since 1998. Promoted at the first class in 2003 and at the exceptional class in 2009.

Research interests

Being the head of a team of more than 40 members, including 20 senior researchers, my research activity can be divided in two research axis. The first one is focused on the development of cutting-edge fluorescence techniques (quantitative two-photon microscopy combining fluorescence lifetime imaging and fluorescence correlation spectroscopy, single molecule spectroscopy, high resolution microscopy such as dSTORM/PALM, STED and AFM/fluorescence microscopy) and innovative environment-sensitive fluorescence probes (notably, environment-sensitive ratiometric probes). The second research axis is focused on the application of these techniques and probes to investigate the properties and functions of HIV-1 proteins. I am especially interested in deciphering the molecular mechanisms of the nucleic acid chaperone properties of the HIV-1 nucleocapsid protein, as well as in characterizing the interactions of this protein with other viral proteins and host proteins. Moreover, based on these investigations, we have designed a number of different classes of molecules able to efficiently inhibit the replication of HIV-1.

Scientific animation

- From 1999-2008, leader of the team “Photophysics of the biomolecular interactions”..
- Since 2009, leader of the team “Biophotonics of the molecular and cellular interactions”. The team got an A+, as the global mark from the AERES in 2009, and 4A+ in 2012.
- Since 2009, head of the Laboratory of Biophotonics and Pharmacology, UMR 7213 CNRS. This laboratory is composed of about 150 members, with about 60 permanent positions.
- From 2003-08, co-director of the French network GDR 2588 CNRS “Functional microscopy of the living” that federates about 80 French public laboratories in the Biophotonics field.
- Since 2011, chair of the PSC of the Methods and Applications in Fluorescence.


- Adrerus thesis prize in 1990.
- Research and doctoral directory bonus from 1993-2009. Excellence research bonus since 2009.
- Honorary Doctor of the National Taras Shevchenko University of Kiev, November 7th, 2011.

National committees
- Member of the national committee of the Universities (39th section) from 1999 to 2004.
- Member of the national committee of the Universities (85th section) from 2009 to 2012.
- Member of the National Committee of the CNRS (30th section) from 2009 to 2012.
- Member of the National Committee of the CNRS (28th section) since 2012.
- Member of the administration council of the Université Louis Pasteur 2002-06.
- Member of the scientific committee of the « Ligue contre le Cancer, région Alsace » 2002-05.
- Member of a committee from the National Agency against AIDS, 2004-08 ;
- Member of numerous selection committees for professor-assistant and professor positions, since 1993.
- Member of the « ANR Blanc » committee, SVSE 5 - Physique, Chimie du vivant et innovations biotechnologiques, since 2013.

Editorial activities

- Editor in chief of Methods and Applications in Fluorescence, since 2012.
- Editor of The protein journal, Open Journal of Biophysics, ISRN Biochemistry, Peer J, Conference papers in biology, Journal of Viruses, Biochemical Compounds, HoAJ Biology
- Referee for international journals (Biochemistry, Nucleic Acids Research, J Am Chem Soc, Langmuir, Tetrahedron, J Phys Chem, Macromolecules…)

Organization of conferences

- Member of the scientific committee of the 1st « International retroviral NC symposium », Frederick, 1997 ; 2nd « International retroviral NC symposium », Lyon, 1999 ; 3rd « International retroviral NC symposium », Annapolis, Maryland (USA), September 2001, 5th « International retroviral NC symposium », Montréal, 18-20 September 2005, 6th « International retroviral NC symposium », Amsterdam, September 2007, 7th « International retroviral NC symposium », Minneapolis, September 2009, 8th « International retroviral NC symposium », Barcelona, 19-21 September, 2011, 9th international retroviral NC symposium, Montreal, 25-28 August 2013.
- Chair of the organizing committee of the 4th international retroviral NC symposium, Illkirch, 14-17 September 2003, 120 participants.
- Nominated in 2006, as a member of the permanent steering committee (PSC) of the Methods and Applications in Fluorescence, which is constituted by 35 world leaders in fluorescence.
- Member of the scientific committee of the 8th conference on Methods and Applications in Fluorescence MAF8, Prague, August 24-27, 2003, MAF10, Salzburg, September 9-12, 2007, MAF11, Budapest, September 6-9, 2009, and MAF13, Genoa September 8-11, 2013
- Chair of the organization committee of the Methods and Applications in Fluorescence MAF12, September 11-14, 2011, 400 participants.
- Chair with R. Pansu of the Organisation of the conference « Chimie pour l’imagerie optique », 8 July 2004, ENS Cachan.
- Member of the scientific committee of the thematic school « Microbiologie fonctionnelle en biologie », Oléron, 12-17 September 2004 and La Grande Motte, 21-26 September 2006.
- Member of the scientific committee of the European workshop on Fluorescence Correlation Spectroscopy Techniques, Paris, 24-25 March 2005.
- Member of the organization committee of the CNRS thematic school « Nanophysics for Health », November 5-9, 2012, Mittelwihr, France
- Member of the scientific committee of Dijon domains. AgroSup, Dijon, November 27-30, 2012.
- Member of the Organization committee « 7th Imaging the cell », August 28-30, 2013, Strasbourg, France.
- Member of the Scientific Committee of “International conference in optics”, April 21-23, 2013, Setif, Algeria

Research contracts

- Agence Nationale de la Recherche (x5, two as coordinator)
- Agence Nationale de la Recherche sur le Sida (x20)
- Sidaction (x3)
- Agence Française contre les myopathies (x3)
- Association de la Recherche contre le Cancer (x3)
- European contracts TRIOH (FP6) and Thinpad (FP7)
- Fondation pour la Recherche Médicale (x 2)
- Sanofi-Pasteur (x5)…)
- Supports for bilateral collaborative projects with Ukraine (x2)
- Turkey, Russia and Chech Republic.
- Member of the ARCUS program (Ukraine, Russia and France).

Publications and conferences

- 240 international publications. 5700 citations. H =43.
- Most productive scientist in HIV-1 nucleocapsid protein within the last 5 years (31 papers, Web of Science).
- Most productive French scientist in fluorescence within the last 5 years (60 papers, Web of Science).
- 100 invited conferences
- 250 posters in national and international conferences
- Direction of 24 PhD thesis (21 defended and 4 in progress). Five of them got a PhD award