Laboratoire de Bioimagerie et Pathologies


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Andreas REISCH

Maître de conférences UNISTRA

Equipe Biophotonique des interactions moléculaires et cellulaires

Bureau/Salle : E 004-E 018

Telephone :(+33) +33 (0)3 68 85 42 66

Courriel : andreas.reisch


Andreas Reisch


Maître de conferences (associate professor) in biophysics

e-mail : reisch

Room : E 004 – E 018

Tel : (+33) (0)3 68 85 42 66



My research focuses on the design of functional polymeric materials for biomedical applications. I am combining polymer synthesis and physical chemistry to assemble materials with precisely defined organization, functionality, and responsiveness. A major aim of my work is to control the interactions between polymeric materials and biological systems. Most recently I am working on ultrabright fluorescent polymer nanoparticles and their use in bioimaging. In this context I coordinate the French young researcher grant (ANR JC/JC) “supertrack” since end of 2016.



I studied chemistry with specialization in polymer chemistry and physical-chemistry at the universities of Stuttgart and Dresden and at the École Européenne de Chimie, Polymères et Matériaux (ECPM) in Strasbourg. My Ph.D. thesis on biomimetic polymer surfaces was prepared under the supervision of Prof. Schaaf and Dr. Mésini at the Institut Charles Sadron, Strasbourg and defended in 2009. During my postdoctoral studies at the Florida State University, Tallahassee, in the group of Prof. Schlenoff I then developed saloplastic polyelectrolyte complexes. A subject I continued working on during a postdoc at the University of Strasbourg alongside the development of mechano-responsive materials, before joining the faculty in 2012.


Protein-sized and Ultrabright Dye-loaded Polymer Nanoparticles for Intracellular Imaging (CLINAM 2018) :

Fluorescent Polymer Nanoparticles for Long-term RGB Coding (CLINAM 2017) :


Some recent publications

(1)  Rosiuk, V. ; Runser, A. ; Klymchenko, A. ; Reisch, A. Controlling Size and Fluorescence of Dye-Loaded Polymer Nanoparticles through Polymer Design. Langmuir 2019, 35 (21), 7009–7017.

(2)  Cardoso Dos Santos, M. ; Runser, A. ; Bartenlian, H. ; Nonat, A. M. ; Charbonnière, L. J. ; Klymchenko, A. S. ; Hildebrandt, N. ; Reisch, A. Lanthanide-Complex-Loaded Polymer Nanoparticles for Background-Free Single-Particle and Live-Cell Imaging. Chem. Mater. 2019, 31 (11), 4034–4041.

(3)  Andreiuk, B. ; Reisch, A. ; Bernhardt, E. ; Klymchenko, A. S. Fighting Aggregation-Caused Quenching and Leakage of Dyes in Fluorescent Polymer Nanoparticles : Universal Role of Counterion. Chem. - Asian J. 2019.

(4)  Reisch, A. ; Heimburger, D. ; Ernst, P. ; Runser, A. ; Didier, P. ; Dujardin, D. ; Klymchenko, A. S. Protein-Sized Dye-Loaded Polymer Nanoparticles for Free Particle Diffusion in Cytosol. Adv. Funct. Mater. 2018, 28 (48), 1805157.

(5)  Reisch, A. ; Trofymchuk, K. ; Runser, A. ; Fleith, G. ; Rawiso, M. ; Klymchenko, A. S. Tailoring Fluorescence Brightness and Switching of Nanoparticles through Dye Organization in the Polymer Matrix. ACS Appl. Mater. Interfaces 2017, 9 (49), 43030–43042.

(6)  Trofymchuk, K. ; Reisch, A. ; Didier, P. ; Fras, F. ; Gilliot, P. ; Mely, Y. ; Klymchenko, A. S. Giant Light-Harvesting Nanoantenna for Single-Molecule Detection in Ambient Light. Nat. Photonics 2017, 11 (10), 657.

(7)  Andreiuk, B. ; Reisch, A. ; Lindecker, M. ; Follain, G. ; Peyriéras, N. ; Goetz, J. G. ; Klymchenko, A. S. Fluorescent Polymer Nanoparticles for Cell Barcoding In Vitro and In Vivo. Small 2017, 13 (38), 1701582.

(8)  Reisch, A. ; Klymchenko, A. S. Fluorescent Polymer Nanoparticles Based on Dyes : Seeking Brighter Tools for Bioimaging. Small 2016, 12 (15), 1968–1992.

(9)  Reisch, A. ; Runser, A. ; Arntz, Y. ; Mély, Y. ; Klymchenko, A. S. Charge-Controlled Nanoprecipitation as a Modular Approach to Ultrasmall Polymer Nanocarriers : Making Bright and Stable Nanoparticles. ACS Nano 2015, 9 (5), 5104–5116.

(10)  Reisch, A. ; Didier, P. ; Richert, L. ; Oncul, S. ; Arntz, Y. ; Mély, Y. ; Klymchenko, A. S. Collective Fluorescence Switching of Counterion-Assembled Dyes in Polymer Nanoparticles. Nat. Commun. 2014, 5, 4089.