Laboratoire de Bioimagerie et Pathologies


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Directeur de recherche (DR2) CNRS

- Responsable

Equipe Signalisation tumorale et cibles thérapeutiques

Bureau/Salle : D207-D219

Telephone :(+33) +33 (0)3 68 85 42 67

Courriel : monique.dontenwill


Recent publications

HAMADI A, BOUALI M, DONTENWILL M, TAKEDA K AND RONDÉ P. Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397. J Cell Science, 2005, 118 : 4415-4425.

MAGLOTT A, BARTIK P, COSGUN S, KLOTZ P, RONDE P, FUHRMANN G, TAKEDA K, MARTIN S and DONTENWILL M. The small α5β1 integrin antagonist, SJ749, reduces proliferation and clonogenicity of human astrocytoma cells. Cancer Research, 2006, 66 : 6002-6007.

MARTIN S, COSSET EC, TERRAND J, MAGLOTT A, TAKEDA K and DONTENWILL M , Caveolin-1 regulates glioma aggressiveness through the control of α5β1 integrin expression and modulates glioblastoma responsiveness to SJ749, an α5β1 integrin antagonist. BBA, Mol Cell Res, 2009, 1793 : 354-367.

ZUBER G., DONTENWILL M, JP BEHR. Synthetic virus-like particles for targeted gene delivery to αvβ3 integrin-presenting endothelial cells. Molecular Pharmaceutics, 2009, 6(5):1544-1552.

MARTINKOVA E, MAGLOTT A, LEGER DL., STIBOROVA M, TAKEDA K, MARTIN S and DONTENWILL M. α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer. 2010, 127 : 1240-1248.

ONCUL S, KLYMCHENKO AS, KUCHERAK OA ; DEMCHENKO AP, MARTIN S, DONTENWILL M, ARNTZ Y, DIDIER P, DUPORTAIL G, MÉLY Y, Liquid ordered phase in cell membranes evidenced by a hydration-sensitive probe : effects of cholesterol depletion and apoptosis. BBA Biomembranes, 2010, 1798 : 1436-1443.

COSSET EC, GODET J, ENTZ-WERLÉ N, GUÉRIN E, GUENOT D, FROELICH S, BONNET D, PINEL S, PLENAT F, CHASTAGNER P, DONTENWILL M AND MARTIN S, Involvement of TGFβ pathway in the regulation of α5β1 integrins by caveolin-1 in human glioblastoma , Int. J. Cancer, 2012, 131 : 601-611.

CREUSAT G, MAGLOTT-ROTH A, PONS B, DONTENWILL M, GUÉRIN E, THOMANN JS, FRISCH B, ZUBER G, Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo , J of controlled release, 2012, 157 : 418-426.

JANOUSKOVA H, MAGLOTT A, LEGER DY, BOSSERT C, NOULET F, GUERIN E, GUENOT D, PINEL S, CHASTAGNER P, PLENAT F, ENTZ-WERLE N, GODET J, MARTIN S and DONTENWILL M., integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high grade glioma. Cancer Research, 2012, 72 : 3463-3470.